ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2013
Iron loading impairs lipoprotein lipase activity and promotes hypertriglyceridemia.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Review
- Moderate iron deficiency and high dietary iron intake differentially alter hepatic lipid metabolism and adipose tissue lipid handling in mice.Frontiers in nutrition · 2025Article
- Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects.Signal transduction and targeted therapy · 2024Review
- Ferroptosis and metabolic syndrome and complications: association, mechanism, and translational applications.Frontiers in endocrinology · 2023Review
- Metabolomic profiling for dyslipidemia in pediatric patients with sickle cell disease, on behalf of the IHCC consortium.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Renal clearable nanochelators for iron overload therapy.Nature communications · 2019Article
- Protective effects of grape seed and skin extract against high-fat-diet-induced lipotoxicity in rat lung.Lipids in health and disease · 2017Article
- Loss of divalent metal transporter 1 function promotes brain copper accumulation and increases impulsivity.Journal of neurochemistry · 2016Article
- Mutation in HFE gene decreases manganese accumulation and oxidative stress in the brain after olfactory manganese exposure.Metallomics : integrated biometal science · 2016Article
- Mechanisms of divalent metal toxicity in affective disorders.Toxicology · 2016Review
- Effect of Hfe Deficiency on Memory Capacity and Motor Coordination after Manganese Exposure by Drinking Water in Mice.Toxicological research · 2015Article
- Article
- Impaired renal function and development in Belgrade rats.American journal of physiology. Renal physiology · 2014Article
- Pathophysiology of the Belgrade rat.Frontiers in pharmacology · 2014Review
- High-fat diet induced an oxidative stress in white adipose tissue and disturbed plasma transition metals in rat: prevention by grape seed and skin extract.The journal of physiological sciences : JPS · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Iron loading is associated with altered lipid metabolism, but underlying mechanisms remain unknown. We compared serum iron and triglycerides (TGs) in Belgrade rats, a genetic model of iron-loading anemia. Homozygous b/b rats had greater serum iron (68 vs. 28 μM; P=0.0004) and TG levels (180 vs. 84 mg/dl; P=0.014) compared to +/b controls. To confirm the association between iron loading and high TGs, Fischer rats were fed chow containing 1% carbonyl iron. Compared to controls pair-fed normal chow, carbonyl iron-fed rats had elevated serum iron (42 vs. 21 μM; P=0.007) and TGs (190 vs. 115 mg/dl; P=0.009). Despite normal hepatic production and secretion, TG clearance was lower in b/b than +/b rats due to reduced serum lipoprotein lipase (LPL) activity (3.1 vs. 5.0 mM/min; P=0.026). Likewise, LPL was lower in carbonyl iron-fed rats compared to controls (2.4 vs. 3.7 mM/min; P=0.017). Direct addition of iron to serum ex vivo or recombinant LPL in vitro decreased enzymatic activity in a dose-dependent manner. Lowering serum iron in Belgrade rats reduced TG levels (274 to 67 mg/dl, P=0.001). This study explains the relationship between iron status and lipid metabolism and provides mechanistic support for interventions that reduce serum iron levels in individuals at risk for hypertriglyceridemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.