ArticleMalaria journal2012
Malaria parasite diversity and transmission intensity affect development of parasitological immunity in a mathematical model.
Article in Malaria journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Agent-based models of malaria transmission: a systematic review.Malaria journal · 2018Pooled it
- Diversity of Chlamydia trachomatis in Trachoma-Hyperendemic Communities Treated With Azithromycin.American journal of epidemiology · 2018Trial
- The time-course of protection of the RTS,S vaccine against malaria infections and clinical disease.Malaria journal · 2015Trial
- Multitask deep learning for the emulation and calibration of an agent-based malaria transmission model.PLoS computational biology · 2025Article
- A Probabilistic Synthesis of Malaria Epidemiology: Exposure, Infection, Parasite Densities, and Detection.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Modelling transmission dynamics and genomic diversity in a recombining parasite population.Wellcome open research · 2024Article
- Spatial dynamics of malaria transmission.PLoS computational biology · 2023Article
- Application of mathematical modelling to inform national malaria intervention planning in Nigeria.Malaria journal · 2023Article
- Plasmodium pitheci malaria in Bornean orang-utans at a rehabilitation centre in West Kalimantan, Indonesia.Malaria journal · 2022Article
- Modeling impact and cost-effectiveness of driving-Y gene drives for malaria elimination in the Democratic Republic of the Congo.Evolutionary applications · 2022Article
- Emulator-based Bayesian optimization for efficient multi-objective calibration of an individual-based model of malaria.Nature communications · 2021Article
- Uncovering the effects of heterogeneity and parameter sensitivity on within-host dynamics of disease: malaria as a case study.BMC bioinformatics · 2021Article
- Seasonality and heterogeneity of malaria transmission determine success of interventions in high-endemic settings: a modeling study.BMC infectious diseases · 2018Article
- Implementation and applications of EMOD, an individual-based multi-disease modeling platform.Pathogens and disease · 2018Article
- Model-Informed Drug Development for Malaria Therapeutics.Annual review of pharmacology and toxicology · 2018Review
- malERA: An updated research agenda for combination interventions and modelling in malaria elimination and eradication.PLoS medicine · 2017Review
- Performance of loop-mediated isothermal amplification (LAMP) for the diagnosis of malaria among malaria suspected pregnant women in Northwest Ethiopia.Malaria journal · 2017Article
- Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Malaria Elimination Campaigns in the Lake Kariba Region of Zambia: A Spatial Dynamical Model.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe development of parasitological immunity against malaria affects the ability to detect infection, the efficiency of the local human parasite reservoir at infecting mosquitoes, and the response to reintroduction of parasites to previously cleared areas. Observations of similar age-trends in detected prevalence and mean parasitaemia across more than an order-of-magnitude of variation in baseline transmission complicate simple exposure-driven explanations.
methodsMathematical models often employ age-dependent immune factors to match the observed trends, while the present model uses a new detailed mechanistic model of parasite transmission dynamics to explain age-trends through the mechanism of parasite diversity. Illustrative simulations are performed for multiple field sites in Tanzania and Nigeria, and observed age-trends and seasonality in parasite prevalence are recreated in silico, proffering possible mechanistic explanations of the observational data.
resultsObserved temporal dynamics in measured parasitaemia are recreated for each location and age-prevalence outputs are studied. Increasing population-level diversity in malaria surface antigens delays development of broad parasitological immunity. A local parasite population with high diversity can recreate the observed trends in age-prevalence across more than an order of magnitude of variation in transmission intensities.
conclusionsMechanistic models of human immunity and parasite antigen diversity can recreate the observed temporal patterns for the development of parasitological immunity across a wide range of transmission intensities. This has implications for the distribution of disease burden across the population, the human transmission reservoir, design of elimination campaigns, and development and roll-out of potential vaccines.
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