ArticleReproductive biology and endocrinology : RB&E2012
Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle.
Article in Reproductive biology and endocrinology : RB&E, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Matrix production and remodeling as therapeutic targets for uterine leiomyoma.Journal of cell communication and signaling · 2014Article
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3 authors at 1 institution in 1 country.
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Abstract
backgroundTo investigate the role of prolyl hydroxylase (PH), a key enzyme of collagen synthesis, in human uterine leiomyoma, PH expression was determined in the normal uterine myometrium and the leiomyoma tissues during the menstrual cycle.
methodsThe tissues were obtained from 40 regularly cycling women (aged 29 to 53 yr) who were undergoing abdominal hysterectomy for symptomatic uterine leiomyoma. Immunohistochemistry for human PH with specific monoclonal antibody was used for analysis.
resultsImmunohistochemical staining for PH revealed intense staining of leiomyoma cells in the uterine leiomyoma throughout the menstrual cycle, as compared with the adjacent normal myometrium. In the secretory phase, weak or no immunostaining for PH was detected in the normal myometrial tissues.
conclusionsThese results suggest that increased expression of PH might play an role in the physiology of uterine leiomyoma during the menstrual cycle.
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