ReviewRadiation oncology (London, England)2012
Radiosurgery with photons or protons for benign and malignant tumours of the skull base: a review.
Review in Radiation oncology (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Protons versus photons for the treatment of chordoma.The Cochrane database of systematic reviews · 2021Pooled it
- Ischemic stroke after radiation therapy for pituitary adenomas: a systematic review.Journal of neuro-oncology · 2017Pooled it
- Novel Bragg peak FLASH radiotherapy: treatment of base-of-skull tumors within existing clinical guidelines.Frontiers in oncology · 2026Article
- Jugular Paraganglioma Presenting As Isolated Hypoglossal Nerve Palsy: An Anatomical Enigma.Cureus · 2025Article
- Quality of life in patients with skull base meningiomas treated with microsurgery: a prospective observational study.Acta neurochirurgica · 2024Observational
- Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors.Neuro-oncology practice · 2024Review
- Utilizing collimated aperture with proton pencil beam scanning (PBS) for stereotactic radiotherapy.Journal of applied clinical medical physics · 2024Article
- Comprehensive assessment of proton plans with three different beam delivery systems for multiple brain metastases.Journal of radiosurgery and SBRT · 2024Article
- The evolving role of reirradiation in the management of recurrent brain tumors.Journal of neuro-oncology · 2023Review
- Long-Term Outcomes after Multimodal Treatment for Clival Chordoma: Efficacy of the Endonasal Transclival Approach with Early Adjuvant Radiation Therapy.Journal of clinical medicine · 2023Article
- Long Term Outcome and Quality of Life of Intracranial Meningioma Patients Treated with Pencil Beam Scanning Proton Therapy.Cancers · 2023Article
- Redefine the Role of Spot-Scanning Proton Beam Therapy for the Single Brain Metastasis Stereotactic Radiosurgery.Frontiers in oncology · 2022Article
- Review
- Gamma Knife Stereotactic Radiosurgery for the treatment of chordomas and chondrosarcomas.Acta neurochirurgica · 2021Article
- Linear Accelerator-Based Radiosurgery of Grade I Intracranial Meningiomas.World neurosurgery: X · 2019Article
- Skull base chordoma treated with proton therapy: A systematic review.Surgical neurology international · 2019Article
- Gamma Knife and volumetric modulated arc therapy stereotactic radiosurgery plan quality and OAR sparing comparison for pituitary adenomas and vestibular schwannomas.Journal of radiosurgery and SBRT · 2018Article
- Fractionated Proton Beam Therapy for Acoustic Neuromas: Tumor Control and Hearing Preservation.International journal of particle therapy · 2018Article
- Surgery and protontherapy in Grade I and II skull base chondrosarcoma: A comparative retrospective study.PloS one · 2018Article
- Hypofractionated high-energy proton-beam irradiation is an alternative treatment for WHO grade I meningiomas.Acta neurochirurgica · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stereotactic radiosurgery (SRS) is an important treatment option for intracranial lesions. Many studies have shown the effectiveness of photon-SRS for the treatment of skull base (SB) tumours; however, limited data are available for proton-SRS.Several photon-SRS techniques, including Gamma Knife, modified linear accelerators (Linac) and CyberKnife, have been developed and several studies have compared treatment plan characteristics between protons and photons.The principles of classical radiobiology are similar for protons and photons even though they differ in terms of physical properties and interaction with matter resulting in different dose distributions.Protons have special characteristics that allow normal tissues to be spared better than with the use of photons, although their potential clinical superiority remains to be demonstrated.A critical analysis of the fundamental radiobiological principles, dosimetric characteristics, clinical results, and toxicity of proton- and photon-SRS for SB tumours is provided and discussed with an attempt of defining the advantages and limits of each radiosurgical technique.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.