ArticleAddiction biology2013
Fronto-striatal functional connectivity during response inhibition in alcohol dependence.
Article in Addiction biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- A meta-analysis of the neural substrates of monetary reward anticipation and outcome in alcohol use disorder.Human brain mapping · 2023Pooled it
- Common neural and transcriptional correlates of inhibitory control underlie emotion regulation and memory control.Social cognitive and affective neuroscience · 2020Pooled it
- Effects of COMT Suppression in a Randomized Trial on the Neural Correlates of Inhibitory Processing Among People With Alcohol Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Trial
- No Effects of rTMS on Performance Monitoring and Attentional Bias in Patients With Alcohol Use Disorder: A Pilot Study.Addiction biology · 2025Trial
- Psilocybin-induced changes in neural reactivity to alcohol and emotional cues in patients with alcohol use disorder: an fMRI pilot study.Scientific reports · 2024Trial
- Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Neuroimaging findings from an experimental pharmacology trial of naltrexone in heavy drinkers of East Asian descent.Drug and alcohol dependence · 2019Trial
- Salience network structural integrity predicts executive impairment in alcohol use disorders.Scientific reports · 2018Trial
- Associations Between Behavioral and Neural Correlates of Inhibitory Control and Amphetamine Reward Sensitivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- The Effects of Pharmacological Opioid Blockade on Neural Measures of Drug Cue-Reactivity in Humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Alcohol attenuates amygdala-frontal connectivity during processing social signals in heavy social drinkers: a preliminary pharmaco-fMRI study.Psychopharmacology · 2013Trial
- Orbitofrontal-ventral striatal coupling: A model of the neurobehavioral architecture of craving in substance use disorders.Cognitive, affective & behavioral neuroscience · 2026Review
- Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.Human brain mapping · 2026Article
- Alterations in the resting-state functional networks are associated with food addiction: an EEG study.Journal of eating disorders · 2025Article
- Modification of inhibitory control and craving through transcranial direct current stimulation as an add-on treatment for substance use disorder: protocol for a randomized controlled study.BMC psychology · 2025Article
- Repeated alcohol drinking in mice is associated with bidirectional alterations in corticostriatal coherence.Neuropharmacology · 2025Article
- Altered effective connectivity of emotion perception and regulation networks during an emotional face perception task in adults with alcohol use disorder.Brain structure & function · 2025Article
- Brain volumes in alcohol use disorder: Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis.Human brain mapping · 2023Article
- Reduced connectivity of the cognitive control neural network at rest in young adults who had their first drink of alcohol prior to age 18.Psychiatry research. Neuroimaging · 2023Article
- Connectome-based predictive modeling of smoking severity using individualized structural covariance network in smokers.Frontiers in neuroscience · 2023Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Poor response inhibition has been implicated in the development of alcohol dependence, yet little is known about how neural pathways underlying cognitive control are affected in this disorder. Moreover, endogenous opioid levels may impact the functionality of inhibitory control pathways. This study investigated the relationship between alcohol dependence severity and functional connectivity of fronto-striatal networks during response inhibition in an alcohol-dependent sample. A secondary aim of this study was to test the moderating effect of a functional polymorphism (A118G) of the μ-opioid receptor (OPRM1) gene. Twenty individuals with alcohol dependence (six females; 90% Caucasian; mean age = 29.4) who were prospectively genotyped on the OPRM1 gene underwent blood oxygen level-dependent functional magnetic resonance imaging while performing a Stop-Signal Task. The relationship between alcohol dependence severity and functional connectivity within fronto-striatal networks important for response inhibition was assessed using psychophysiological interaction analyses. Analyses revealed greater alcohol dependence severity was associated with weaker functional connectivity between the putamen and prefrontal regions (e.g. the anterior insula, anterior cingulate and medial prefrontal cortex) during response inhibition. Furthermore, the OPRM1 genotype was associated with differential response inhibition-related functional connectivity. This study demonstrates that individuals with more severe alcohol dependence exhibit less frontal connectivity with the striatum, a component of cognitive control networks important for response inhibition. These findings suggest that the fronto-striatal pathway underlying response inhibition is weakened as alcoholism progresses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.