ArticleBrain connectivity2012
Disrupted brain networks in the aging HIV+ population.
Article in Brain connectivity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02571504 (Brain Imaging to Understand HIV-associated Neurocognitive Disorder and Predict Response to Cognitive Training), which is not on this map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Brain Imaging to Understand HIV-associated Neurocognitive Disorder and Predict Response to Cognitive Training
Who cites it
49 citing papers in PubMed, 62 citations in OpenAlex.
- Altered White Matter Tracts in the Somatosensory, Salience, Motor, and Default Mode Networks in 7-Year-Old Children Living with Human Immunodeficiency Virus: A Tractographic Analysis.Brain connectivity · 2022Article
- Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: A pharmacokinetic and pharmacodynamics perspective.Neurotoxicology · 2022Review
- Rich-Club Analysis of Structural Brain Network Alterations in HIV Positive Patients With Fully Suppressed Plasma Viral Loads.Frontiers in neurology · 2022Article
- Neurological pathophysiology of SARS-CoV-2 and pandemic potential RNA viruses: a comparative analysis.FEBS letters · 2021Review
- Validity of Digital Assessments in Screening for HIV-Related Cognitive Impairment: a Review.Current HIV/AIDS reports · 2021Review
- Neuroimaging Advances in Diagnosis and Differentiation of HIV, Comorbidities, and Aging in the cART Era.Current topics in behavioral neurosciences · 2021Article
- Detecting cognitive impairment in HIV-infected individuals using mutual connectivity analysis of resting state functional MRI.Journal of neurovirology · 2020Article
- Targeted Mitochondrial COQMolecular pharmaceutics · 2019Article
- Information processing deficit in older adults with HIV infection: A comparison with Parkinson's disease.Neuropsychology · 2019Article
- Effects of early HIV infection and combination antiretroviral therapy on intrinsic brain activity: a cross-sectional resting-state fMRI study.Neuropsychiatric disease and treatment · 2019Article
- Aging and Apolipoprotein E in HIV Infection.Journal of neurovirology · 2018Review
- A critical evaluation of validity and utility of translational imaging in pain and analgesia: Utilizing functional imaging to enhance the process.Neuroscience and biobehavioral reviews · 2018Review
- The Aging Brain With HIV Infection: Effects of Alcoholism or Hepatitis C Comorbidity.Frontiers in aging neuroscience · 2018Review
- Alteration of brain network topology in HIV-associated neurocognitive disorder: A novel functional connectivity perspective.NeuroImage. Clinical · 2018Article
- Human Immunodeficiency Virus in the Brain-Culprit or Facilitator?Infectious diseases · 2018Review
- Resting-state subcortical functional connectivity in HIV-infected patients on long-term cART.Brain imaging and behavior · 2017Article
- Apolipoprotein E4 Suppresses Neuronal-Specific Gene Expression in Maturing Neuronal Progenitor Cells Exposed to HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017Article
- Topological Organization of Whole-Brain White Matter in HIV Infection.Brain connectivity · 2017Article
- ApoE ε4 Is Associated With Cognition, Brain Integrity, and Atrophy in HIV Over Age 60.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Extracting patterns of morphometry distinguishing HIV associated neurodegeneration from mild cognitive impairment via group cardinality constrained classification.Human brain mapping · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Antiretroviral therapies have become widely available, and as a result, individuals infected with the human immunodeficiency virus (HIV) are living longer, and becoming integrated into the geriatric population. Around half of the HIV+ population shows some degree of cognitive impairment, but it is unknown how their neural networks and brain connectivity compare to those of noninfected people. Here we combined magnetic resonance imaging-based cortical parcellations with high angular resolution diffusion tensor imaging tractography in 55 HIV-seropositive patients and 30 age-matched controls, to map white matter connections between cortical regions. We set out to determine selective virus-associated disruptions in the brain's structural network. All individuals in this study were aged 60-80, with full access to antiretroviral therapy. Frontal and motor connections were compromised in HIV+ individuals. HIV+ people who carried the apolipoprotein E4 allele (ApoE4) genotype-which puts them at even greater risk for neurodegeneration-showed additional network structure deficits in temporal and parietal connections. The ApoE4 genotype interacted with duration of illness. Carriers showed greater brain network inefficiencies the longer they were infected. Neural network deficiencies in HIV+ populations exceed those typical of normal aging, and are worse in those genetically predisposed to brain degeneration. This work isolates neuropathological alterations in HIV+ elders, even when treated with antiretroviral therapy. Network impairments may contribute to the neuropsychological abnormalities in elderly HIV patients, who will soon account for around half of all HIV+ adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.