Evidence map›Paper›PMID 23240086›Full record

ArticleeLife2012

Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex.

Tsutomu Aoki, Ali Sarkeshik, John Yates, Paul Schedl

Abstract read
In one paragraph

Article in eLife, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
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  3. ThebioRxiv : the preprint server for biology · 2025
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  15. Complete reconstitution of bypass and blocking functions in a minimal artificialProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tsutomu AokiDepartment of Molecular Biology , Princeton University , Princeton , United States.
Ali Sarkeshik
John Yates
Paul Schedl

Funding

ZDS2P REGULATES SWE1P-DEPENDENT POLARIZED CELL GROWTH IN S CEREVISIAEP41RR011823 · NCRR · UNIVERSITY OF WASHINGTON · PI DAVIS, TRACY · 1996 to 2011
$24.7M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2012 to 2021
$20.7M
NCRR NIH HHS P41 RR011823NIGMS NIH HHS GM043432NIGMS NIH HHS P41 GM103533
6 · The paper itself

Abstract

Chromatin boundaries subdivide eukaryotic chromosomes into functionally autonomous domains of genetic activity. This subdivision insulates genes and/or regulatory elements within a domain from promiscuous interactions with nearby domains. While it was previously assumed that the chromosomal domain landscape is fixed, there is now growing evidence that the landscape may be subject to tissue and stage specific regulation. Here we report the isolation and characterization of a novel developmentally restricted boundary factor, Elba. We show that Elba is an unusual hetero-tripartite protein complex that requires all three proteins for DNA binding and insulator activity.DOI:http://dx.doi.org/10.7554/eLife.00171.001.

Indexed as

Amino Acid SequenceAnimalsChromatinDNADNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsEmbryo, NonmammalianGene Expression Regulation, DevelopmentalHumansInsulator ElementsMolecular Sequence DataNuclear ProteinsProtein IsoformsProtein MultimerizationRepressor ProteinsBsg25A protein, DrosophilaChromatinDNADNA-Binding ProteinsDrosophila ProteinsElba2 protein, DrosophilaElba3 protein, DrosophilaNuclear ProteinsProtein IsoformsRepressor ProteinsTranscription FactorsBithoraxBoundariesChromatinDevelopmentD. melanogasterDomainsInsulators

Identifiers

PMID23240086
PMCPMC3510454

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.