ArticlePloS one2012
A systems approach to rheumatoid arthritis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Extracellular vesicle digital scoring assay for assessment of treatment responses in hepatocellular carcinoma patients.Journal of experimental & clinical cancer research : CR · 2025Article
- Role of Data in Development and Application of Quantitative Systems Pharmacology Models.Handbook of experimental pharmacology · 2025Review
- Identifying the Potential Differentially Expressed miRNAs and mRNAs in Osteonecrosis of the Femoral Head Based on Integrated Analysis.Clinical interventions in aging · 2021Article
- Identification of RELN variant p.(Ser2486Gly) in an Iranian family with ankylosing spondylitis; the first association of RELN and AS.European journal of human genetics : EJHG · 2020Article
- Compendium of synovial signatures identifies pathologic characteristics for predicting treatment response in rheumatoid arthritis patients.Clinical immunology (Orlando, Fla.) · 2019Article
- An integrative transcriptome analysis framework for drug efficacy and similarity reveals drug-specific signatures of anti-TNF treatment in a mouse model of inflammatory polyarthritis.PLoS computational biology · 2019Article
- Prevalence of comorbidities in Mexican mestizo patients with rheumatoid arthritis.Rheumatology international · 2017Observational
- Identification of key genes associated with rheumatoid arthritis with bioinformatics approach.Medicine · 2017Article
- Assessment of six cardiovascular risk calculators in Mexican mestizo patients with rheumatoid arthritis according to the EULAR 2015/2016 recommendations for cardiovascular risk management.Clinical rheumatology · 2017Article
- Rheumatoid arthritis: Modelling cytokine signalling networks.Nature reviews. Rheumatology · 2017Article
- Comparison of statin eligibility according to the Adult Treatment Panel III, ACC/AHA blood cholesterol guideline, and presence of carotid plaque by ultrasound in Mexican mestizo patients with rheumatoid arthritis.Clinical rheumatology · 2016Observational
- Integrated Classification of Prostate Cancer Reveals a Novel Luminal Subtype with Poor Outcome.Cancer research · 2016Article
- The dynamic evolution of rheumatology in Korea.Nature reviews. Rheumatology · 2016Review
- Applications of systems approaches in the study of rheumatic diseases.The Korean journal of internal medicine · 2015Review
- Identification of key regulators for the migration and invasion of rheumatoid synoviocytes through a systems approach.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Protein-protein interaction networks (PPI) and complex diseases.Gastroenterology and hepatology from bed to bench · 2014Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily attacks synovial joints. Despite the advances in diagnosis and treatment of RA, novel molecular targets are still needed to improve the accuracy of diagnosis and the therapeutic outcomes. Here, we present a systems approach that can effectively 1) identify core RA-associated genes (RAGs), 2) reconstruct RA-perturbed networks, and 3) select potential targets for diagnosis and treatments of RA. By integrating multiple gene expression datasets previously reported, we first identified 983 core RAGs that show RA dominant differential expression, compared to osteoarthritis (OA), in the multiple datasets. Using the core RAGs, we then reconstructed RA-perturbed networks that delineate key RA associated cellular processes and transcriptional regulation. The networks revealed that synovial fibroblasts play major roles in defining RA-perturbed processes, anti-TNF-α therapy restored many RA-perturbed processes, and 19 transcription factors (TFs) have major contribution to deregulation of the core RAGs in the RA-perturbed networks. Finally, we selected a list of potential molecular targets that can act as metrics or modulators of the RA-perturbed networks. Therefore, these network models identify a panel of potential targets that will serve as an important resource for the discovery of therapeutic targets and diagnostic markers, as well as providing novel insights into RA pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.