ArticlePloS one2012
doublesex functions early and late in gustatory sense organ development.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Using a female-specific isoform ofiScience · 2025Article
- Single-nucleus transcriptomics of wing sexual dimorphism and scale cell specialization in sulphur butterflies.PLoS biology · 2025Article
- Article
- Secondary reversion to sexual monomorphism associated with tissue-specific loss of doublesex expression.Evolution; international journal of organic evolution · 2022Article
- Sex-specific evolution of a Drosophila sensory system via interacting cis- and trans-regulatory changes.Evolution & development · 2022Article
- Article
- Tissue-specific developmental regulation and isoform usage underlie the role ofRoyal Society open science · 2020Article
- Doublesex Mediates the Development of Sex-Specific Pheromone Organs in Bicyclus Butterflies via Multiple Mechanisms.Molecular biology and evolution · 2020Article
- Article
- Modular tissue-specific regulation ofDevelopment (Cambridge, England) · 2019Article
- Article
- Activity-dependent visualization and control of neural circuits for courtship behavior in the flyProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Evolving doublesex expression correlates with the origin and diversification of male sexual ornaments in the Drosophila immigrans species group.Evolution & development · 2018Article
- apterous Brain Neurons Control Receptivity to Male Courtship in Drosophila Melanogaster Females.Scientific reports · 2017Article
- Sex-specific regulation of Lgr3 in Drosophila neurons.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Double nexus--Doublesex is the connecting element in sex determination.Briefings in functional genomics · 2015Review
- The Drosophila IR20a clade of ionotropic receptors are candidate taste and pheromone receptors.Neuron · 2014Article
- doublesex is a mimicry supergene.Nature · 2014Article
- Multiple recent co-options of Optix associated with novel traits in adaptive butterfly wing radiations.EvoDevo · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Somatic sexual dimorphisms outside of the nervous system in Drosophila melanogaster are largely controlled by the male- and female-specific Doublesex transcription factors (DSX(M) and DSX(F), respectively). The DSX proteins must act at the right times and places in development to regulate the diverse array of genes that sculpt male and female characteristics across a variety of tissues. To explore how cellular and developmental contexts integrate with doublesex (dsx) gene function, we focused on the sexually dimorphic number of gustatory sense organs (GSOs) in the foreleg. We show that DSX(M) and DSX(F) promote and repress GSO formation, respectively, and that their relative contribution to this dimorphism varies along the proximodistal axis of the foreleg. Our results suggest that the DSX proteins impact specification of the gustatory sensory organ precursors (SOPs). DSX(F) then acts later in the foreleg to regulate gustatory receptor neuron axon guidance. These results suggest that the foreleg provides a unique opportunity for examining the context-dependent functions of DSX.
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Registered trials
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