ArticleThe Yale journal of biology and medicine2012
Environmental enrichment: aging and memory.
Article in The Yale journal of biology and medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Environmental Enrichment Attenuates Aging-Induced BBB Disruption and Cognitive Impairment with Activation of FNDC5/Irisin Signaling.International journal of molecular sciences · 2026Article
- Article
- Environmental Enrichment Improves the Recognition Memory in Adult Mice Following Social Isolation via Downregulation of Kv4.2 Potassium Channels.Molecular neurobiology · 2024Article
- Overnight olfactory enrichment using an odorant diffuser improves memory and modifies the uncinate fasciculus in older adults.Frontiers in neuroscience · 2023Review
- A Conceptual View of Cognitive Intervention in Older Adults With and Without Cognitive Decline-A Systemic Review.Frontiers in aging · 2022Review
- Neuroarchitecture Assessment: An Overview and Bibliometric Analysis.European journal of investigation in health, psychology and education · 2021Review
- Article
- Social housing protects against age-related working memory decline independently of physical enrichment in rats.Neurobiology of aging · 2019Article
- Environmental Enrichment and Successful Aging.Frontiers in behavioral neuroscience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A decline in learning and memory is a feature of the normal aging process and associated with neurodegenerative diseases such as dementia and Alzheimer's disease. Moreover, certain forms of dementia and memory loss are inevitable due to the normal aging process. The unavoidable effect of age on memory is an ongoing study, as the findings assist in identifying cortical functions of the brain. Histone acetylation is a mechanism in synaptic plasticity and a key function in learning and memory because changes within the process alter gene transcription and the quantity of synthesized proteins. Similar to histone acetylation, environmental enrichment has also been found to improve memory formation by stimulating synaptic plasticity. Through understanding the mechanisms by which environmental enrichment and histone acetylation interact in the brain and affect learning and memory, novel applications can be developed for therapeutic interventions to neurodegenerative diseases and aging.
Indexed as
Identifiers
23239950PMC3516891W164240696What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.