Evidence map›Paper›PMID 23239843›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2013

Subjective responses to oral tobacco products: scale validation.

Dorothy K Hatsukami, Yan Zhang, Richard J O'Connor, Herb H Severson

2 registry-linked trialsAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03719391 nacompletednot on this mapstarted 2018, after this paper: background citation

A Randomized, Open-Label, Cross-Over Study to Assess Nicotine Uptake and Subjective Measures With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) Compared to Usual Brand Combustible Cigarettes, a Comparator E-Cigarette, and Nicotine Gum in Healthy Adult Smokers

TypeinterventionalSponsorJuul Labs, Inc.Ran2018 to 2018Enrolled67ConditionsNicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco SmokingArmsVirginia Tobacco flavored JUUL 5% ENDS, Cool Mint flavored JUUL 5% ENDS, Mango flavored JUUL 5% ENDS, Creme Brulee flavored JUUL 5% ENDS, VUSE Solo e-cigarette
NCT04123041 nacompletednot on this mapstarted 2019, after this paper: background citation

A Randomized, Open-Label, Cross-Over Study to Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems With Multiple Flavors and Nicotine Concentrations, Usual Brand of Combustible Cigarettes, a Comparator E-Cigarette and Nicotine Gum in Adult Smokers

TypeinterventionalSponsorJuul Labs, Inc.Ran2019 to 2019Enrolled137ConditionsElectronic Cigarette Use, Tobacco SmokingArmsJUUL ENDS, Combustible cigarette, comparator e-cigarette, Nicorette gum
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Abuse Liability of Electronic Cigarettes in Never-Smoking Electronic Cigarette Users.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
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  12. The Impact of E-liquid Propylene Glycol and Vegetable Glycerin Ratio on Ratings of Subjective Effects, Reinforcement Value, and Use in Current Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
    Trial
  13. Trial
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  15. Acute effects of snus in never-tobacco users: a pilot study.The American journal of drug and alcohol abuse · 2018
    Trial
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  18. Perceived Health Risks of Snus and Medicinal Nicotine Products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016
    Trial
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dorothy K HatsukamiUniversity of Minnesota, Department of Psychiatry, Minneapolis, MN 55414, USA. hatsu001@umn.edu
Yan Zhang
Richard J O'Connor
Herb H Severson

Funding

Tobacco Constituent and Biomarker Assessment CoreU19CA157345 · NCI · UNIVERSITY OF MINNESOTA · PI HATSUKAMI, DOROTHY K · 2012 to 2016
$13.3M
Evaluation of Oral Tobacco as a Harm Reduction Method for SmokersR01CA135884 · NCI · UNIVERSITY OF MINNESOTA · PI HATSUKAMI, DOROTHY K · 2008 to 2013
$2.7M
NCI NIH HHS R01 CA135884NCI NIH HHS U19 CA157345
6 · The paper itself

Abstract

introductionSeveral noncombusted oral tobacco products have been introduced that are primarily marketed to cigarette smokers. An important component of evaluating these products involves assessment of subjective responses to the product. To date, few studies have been undertaken to examine the validity of subjective response questionnaires for oral tobacco products. The goal of this study is to examine the extent subjective responses to a product are related to product preference and extent of product use.

methodsData from a study examining oral tobacco product preference were used. Smokers were asked to sample a variety of oral tobacco products that differed in formulation (snus versus dissolvables) and dose of nicotine. At the end of the sampling period, subjects were asked to choose the product that they would use to completely substitute for cigarettes for the next 2 weeks. During the sampling period, subjects completed a Product Evaluation Scale (PES) that describes subjective responses to the product. During the treatment phase, they kept record of amount of product use.

resultsSubjective responses to the product on the PES were related to product choice and to some extent, the amount of product use. Product choice was associated with different characteristics of the product and smoker needs.

conclusionThe PES may be a useful tool for the evaluation or oral tobacco products.

Indexed as

Patient SatisfactionTobacco, SmokelessAdultFemaleHumansMaleMarketingMiddle AgedMinnesotaOregonSmokingSmoking CessationSurveys and Questionnaires

Identifiers

PMID23239843
PMCPMC3682844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.