ArticleAmerican journal of respiratory and critical care medicine2013
Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome.
Article in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Bronchoalveolar lavage for supporting acute cellular rejection in lung transplant recipients: A retrospective analysis.JHLT open · 2026Article
- Basiliximab induction immunosuppression and lung transplant outcomes: Propensity analysis in a multicenter cohort.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- Prognosis and Risks for Probable Chronic Lung Allograft Dysfunction: A Prospective Multicenter Study.American journal of respiratory and critical care medicine · 2025Article
- Small airway brush gene expression predicts chronic lung allograft dysfunction and mortality.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- Airway epithelium in lung transplantation: a potential actor for post-transplant complications?European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Short airway telomeres are associated with primary graft dysfunction and chronic lung allograft dysfunction.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Decreased Lymphocytic Bronchitis Severity in the Era of Azithromycin Prophylaxis.Transplantation direct · 2023Article
- Frailty and genetic risk predict fracture after lung transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- CD16American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- Clinical relevance of cell-free DNA quantification and qualification during the first month after lung transplantation.Frontiers in immunology · 2023Article
- NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.JCI insight · 2022Article
- Lymphocytic Airway Inflammation in Lung Allografts.Frontiers in immunology · 2022Review
- Beyond Bronchiolitis Obliterans: In-Depth Histopathologic Characterization of Bronchiolitis Obliterans Syndrome after Lung Transplantation.Journal of clinical medicine · 2021Article
- Chronic lung allograft dysfunction small airways reveal a lymphocytic inflammation gene signature.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Surveillance for acute cellular rejection after lung transplantation.Annals of translational medicine · 2020Review
- Dectin-1 genetic deficiency predicts chronic lung allograft dysfunction and death.JCI insight · 2019Article
- Gene signatures common to allograft rejection are associated with lymphocytic bronchitis.Clinical transplantation · 2019Article
- [Lung transplantation : Histomorphological diagnosis and clinical aspects].Der Pathologe · 2019Article
- NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients.Transplantation · 2019Article
- Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients.Clinical transplantation · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleLung transplantation offers great promise for otherwise terminal lung diseases, but the development of bronchiolitis obliterans syndrome (BOS) continues to limit survival. Although acute rejection and lymphocytic bronchiolitis have been identified as risk factors for the development of BOS, it is unclear whether large-airway lymphocytic inflammation conveys the same risk.
objectivesWe evaluated lymphocytic bronchitis on endobronchial biopsies as a risk factor for BOS and mortality.
methodsEndobronchial biopsies were collected and graded during surveillance after lung transplantation. We assessed samples with negative cultures collected in the first 90 days from 298 subjects and compared large-airway lymphocytic bronchitis assessed by a 0-2 "E-score" and with standard A and BR pathology scores for acute rejection and small-airway lymphocytic bronchiolitis, respectively. MEASUREMENTS AND MAIN
resultsWe found surprisingly little association between large- and small-airway lymphocytic inflammation scores from a given bronchoscopy. Endobronchial lymphocytic bronchitis was more prevalent in subjects in BOS stage 0p and BOS stages 1-3 at the time of biopsy. Within 90 days after transplantation, increasing maximum E-score was associated with greater risk of BOS (adjusted hazard ratio, 1.76; 95% confidence interval, 1.11-2.78; P = 0.02) and in this analysis 90-day maximum E-scores were the only score type predictive of BOS (P < 0.01).
conclusionsThese results support a multicenter study to evaluate endoscopic biopsies for the identification of patients at increased risk for BOS. The association of endobronchial lymphocytic inflammation and BOS may have mechanistic implications.
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