ArticleJournal of assisted reproduction and genetics2013
An insufficient increase of cytosolic free calcium level results postovulatory aging-induced abortive spontaneous egg activation in rat.
Article in Journal of assisted reproduction and genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- The NADJournal of assisted reproduction and genetics · 2024Article
- Spontaneous Overactivation ofInternational journal of molecular sciences · 2024Article
- Diminished NAD+ levels and activation of retrotransposons promote postovulatory aged oocyte (POAO) death.Cell death discovery · 2024Article
- Proteomic analysis implicates that postovulatory aging leads to aberrant gene expression, biosynthesis, RNA metabolism and cell cycle in mouse oocytes.Journal of ovarian research · 2022Article
- In vivo and in vitro postovulatory aging: when time works against oocyte quality?Journal of assisted reproduction and genetics · 2022Review
- Meiotic Instability Generates a Pathological Condition in Mammalian Ovum.Stem cell reviews and reports · 2021Review
- Oocyte Spontaneous Activation: An Overlooked Cellular Event That Impairs Female Fertility in Mammals.Frontiers in cell and developmental biology · 2021Review
- Biochemical Hallmarks of Oxidative Stress-Induced Overactivation ofBioMed research international · 2019Article
- Postovulatory cell death: why eggs die via apoptosis in biological species with external fertilization.The Journal of reproduction and development · 2018Review
- Increased level of reactive oxygen species persuades postovulatory aging-mediated spontaneous egg activation in rat eggs cultured in vitro.In vitro cellular & developmental biology. Animal · 2016Article
- Nitric oxide signals postovulatory aging-induced abortive spontaneous egg activation in rats.Redox report : communications in free radical research · 2015Article
- Morphological, cellular and molecular changes during postovulatory egg aging in mammals.Journal of biomedical science · 2015Review
- Structure of a DsbF homologue from Corynebacterium diphtheriae.Acta crystallographica. Section F, Structural biology communications · 2014Article
- RyR channel-mediated increase of cytosolic free calcium level signals cyclin B1 degradation during abortive spontaneous egg activation in rat.In vitro cellular & developmental biology. Animal · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe present study was aimed to find out whether postovulatory aging-induced abortive spontaneous egg activation (SEA) is due to insufficient increase of cytosolic free Ca(2+) level.
methodsImmature female rats (22-24 days old) were subjected to superovulation induction protocol. Eggs were collected 14, 17 and 19 h post-hCG surge to induce in vivo egg aging. The eggs were collected 14 h post-hCG surge and cultured in vitro for 3, 5 and 7 h to induce in vitro egg aging. The morphological changes, rate of abortive SEA, chromosomal status and cytosolic free Ca(2+) levels were analyzed.
resultsPostovulatory aging induced morphological features characteristics of abortive SEA in a time-dependent manner in vivo as well as in vitro. The extracellular Ca(2+) increased rate of abortive SEA during initial period of culture, while co-addition of a nifedipine (L-type Ca(2+) channel blocker) protected against postovulatory aging-induced abortive SEA. However, CI induced morphological features characteristics of egg activation (EA) in a dose-dependent manner. As compare to control, an increase of cytosolic free Ca(2+) level (1.42 times) induced abortive SEA, while further increase of cytosolic free Ca(2+) level (2.55 times) induced EA.
conclusionOur results show that an insufficient cytosolic free Ca(2+) level is associated with postovulatory aging -induced abortive SEA, while furthermore increase is required to induce EA in rat.
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