Evidence map›Paper›PMID 23239123›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2013

Empirically driven definitions of "good," "moderate," and "poor" levels of functioning in the treatment of schizophrenia.

Haya Ascher-Svanum, Diego Novick, Josep Maria Haro, Jaume Aguado, Zhanglin Cui

Abstract read
In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. How to interpret multidimensional quality of life questionnaires for patients with schizophrenia?Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haya Ascher-SvanumLilly Research Laboratories, US Outcomes Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA, ASCHER-SVANUM_HAYA@LILLY.COM.
Diego Novick
Josep Maria Haro
Jaume Aguado
Zhanglin Cui

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study used an empirical approach to identify and validate the classification of patients with schizophrenia in "good," "moderate," or "poor" functioning groups based on the assessment of functional measures.

methodsUsing data from a study of schizophrenia outpatients, patients were classified into functional groups using cluster analysis based on the Heinrich-Carpenter Quality of Life Scale (QLS), the 36-item Short-Form Health Survey (SF-36) Mental Component Summary Score, and a productivity measure. A three-cluster solution was chosen. Concurrent, convergent, and discriminant validity were assessed. Criteria for classifying patient functioning as "good," "moderate," or "poor" were established using classification and regression tree analysis.

resultsThe three clusters consistently differentiated patients on the QLS, SF-36 Mental Component Summary Score, and productivity measure. The clusters also differed on other functional measures and were concordant with previous functional classifications. Concurrent, convergent, and discriminant validity were good. "Good" functioning was identified as a QLS total score ≥ 84.5; "moderate" and "poor" functioning were separated by a cutoff score of 15.5 on the QLS intrapsychic foundation domain. Sensitivity ranged from 86 to 93 % and specificity from 89 to 99 %.

conclusionsThe heterogeneity in functioning of schizophrenia patients can be classified reliably in an empirical manner using specific cutoff scores on commonly used functional measures.

Indexed as

Schizophrenic PsychologyActivities of Daily LivingAdultAgedAntipsychotic AgentsBenzodiazepinesCluster AnalysisCross-Sectional StudiesFemaleHealth Care SurveysHumansMaleMiddle AgedOutcome Assessment, Health CarePsychiatric Status Rating ScalesQuality of LifeAntipsychotic AgentsBenzodiazepines

Identifiers

PMID23239123
PMCPMC3825592

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.