ReviewAmino acids2013
Nutritionally essential amino acids and metabolic signaling in aging.
Review in Amino acids, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Effects of 12 Weeks of Essential Amino Acids (EAA)-Based Multi-Ingredient Nutritional Supplementation on Muscle Mass, Muscle Strength, Muscle Power and Fatigue in Healthy Elderly Subjects: A Randomized Controlled Double-Blind Study.The journal of nutrition, health & aging · 2019Trial
- Trial
- Double-blind, placebo-controlled pilot trial of L-Leucine-enriched amino-acid mixtures on body composition and physical performance in men and women aged 65-75 years.European journal of clinical nutrition · 2016Trial
- Dietary Preferences and Sarcopenia in Young and Middle-Aged Adults: A Population-Based Correlational Study.Nutrients · 2026Article
- Achieving High Protein Quality Is a Challenge in Vegan Diets: A Narrative Review.Nutrition reviews · 2025Review
- Serine metabolism in aging and age-related diseases.GeroScience · 2025Review
- Comparative Impact of Organic Grass-Fed and Conventional Cattle-Feeding Systems on Beef and Human Postprandial Metabolomics-A Randomized Clinical Trial.Metabolites · 2024Article
- Intensive care unit-acquired weakness: Recent insights.Journal of intensive medicine · 2024Review
- Molecular Mechanisms Underlying Intensive Care Unit-Acquired Weakness and Sarcopenia.International journal of molecular sciences · 2022Review
- Exploratory Analysis of Selected Components of the mTOR Pathway Reveals Potentially Crucial Associations with Childhood Malnutrition.Nutrients · 2022Article
- Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration.Molecular neurodegeneration · 2021Review
- Review
- Taurine Attenuates Catabolic Processes Related to the Onset of Sarcopenia.International journal of molecular sciences · 2020Article
- Fast quantification of free amino acids in food by microfluidic voltage-assisted liquid desorption electrospray ionization-tandem mass spectrometry.Analytical and bioanalytical chemistry · 2020Article
- Exploring the Preventive Effect and Mechanism of Senile Sarcopenia Based on "Gut-Muscle Axis".Frontiers in bioengineering and biotechnology · 2020Review
- Amino acids and amino acid sensing: implication for aging and diseases.Biogerontology · 2019Review
- Impact of a High Protein Intake on the Plasma Metabolome in Elderly Males: 10 Week Randomized Dietary Intervention.Frontiers in nutrition · 2019Article
- Dietary Protein and Muscle in Aging People: The Potential Role of the Gut Microbiome.Nutrients · 2018Review
- The Beneficial Effects of Taurine to Counteract Sarcopenia.Current protein & peptide science · 2018Review
- Higher Concentrations of BCAAs and 3-HIB Are Associated with Insulin Resistance in the Transition from Gestational Diabetes to Type 2 Diabetes.Journal of diabetes research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Aging is associated with a gradual decline in skeletal muscle mass and strength leading to increased risk for functional impairments. Although basal rates of protein synthesis and degradation are largely unaffected with age, the sensitivity of older muscle cells to the anabolic actions of essential amino acids appears to decline. The major pathway through which essential amino acids induce anabolic responses involves the mammalian target of rapamycin (mTOR) Complex 1, a signaling pathway that is especially sensitive to regulation by the branched chain amino acid leucine. Recent evidence suggests that muscle of older individuals require increasing concentrations of leucine to maintain robust anabolic responses through the mTOR pathway. While the exact mechanisms for the age-related alterations in nutritional signaling through the mTOR pathway remain elusive, there is increasing evidence that decreased sensitivity to insulin action, reductions in endothelial function, and increased oxidative stress may be underlying factors in this decrease in anabolic sensitivity. Ensuring adequate nutrition, including sources of high quality protein, and promoting regular physical activity will remain among the frontline defenses against the onset of sarcopenia in older individuals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.