ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2013
Expression of bile acid receptor TGR5 in gastric adenocarcinoma.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 97 citations in OpenAlex.
- The dual role of gastric microbiota dysbiosis in gastric cancer progression and therapy.International journal of clinical oncology · 2026Review
- Ursodeoxycholic acid alleviates α-Casein-induced cow's milk protein allergy via the TGR5/NF-κB signaling pathway.Scientific reports · 2026Article
- Gut metabolites: key factors in the cross-talk between the gut microbiota and tumor immunotherapy.Frontiers in immunology · 2026Review
- Effect of bile reflux on gastric juice microbiota in patients with different histology phenotypes.Gut pathogens · 2024Article
- Collaborative Metabolism: Gut Microbes Play a Key Role in Canine and Feline Bile Acid Metabolism.Veterinary sciences · 2024Review
- Alteration of serum bile acids in non-small cell lung cancer identified by a validated LC-MS/MS method.Journal of cancer research and clinical oncology · 2023Article
- Microbial Metabolite Dysbiosis and Colorectal Cancer.Gut and liver · 2023Review
- Microbiota of the gastrointestinal tract: Friend or foe?World journal of gastroenterology · 2023Review
- Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori-induced inflammation-driven gastric carcinogenesis.The Journal of clinical investigation · 2022Article
- Bile Acid-Microbiome Interaction Promotes Gastric Carcinogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- The role of bile acids in carcinogenesis.Cellular and molecular life sciences : CMLS · 2022Review
- Roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review.Cell death discovery · 2022Review
- Primary bile acid activates Egr‑1 expression through the MAPK signaling pathway in gastric cancer.Molecular medicine reports · 2022Article
- GPBAR1 promotes proliferation and is related to poor prognosis of high-grade glioma via inducing MAFB expression.Histology and histopathology · 2022Article
- TGR5 deficiency activates antitumor immunity in non-small cell lung cancerActa pharmaceutica Sinica. B · 2022Article
- Alterations in the gastric microbiota and metabolites in gastric cancer: An update review.Frontiers in oncology · 2022Review
- The role of TGR5 as an onco-immunological biomarker in tumor staging and prognosis by encompassing the tumor microenvironment.Frontiers in oncology · 2022Article
- Interplay between Dysbiosis of Gut Microbiome, Lipid Metabolism, and Tumorigenesis: Can Gut Dysbiosis Stand as a Prognostic Marker in Cancer?Disease markers · 2022Review
- High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review.Cells · 2021Review
- Ursodeoxycholic acid suppresses the malignant progression of colorectal cancer through TGR5-YAP axis.Cell death discovery · 2021Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Bile reflux is a risk factor in the development of intestinal metaplasia in the stomach and is believed to function as an initiator of gastric carcinogenesis. However, whether the G protein-coupled bile acid receptor TGR5 is expressed in this tumor is not known. In this study, we determined the expression of TGR5 in gastric adenocarcinoma and examined the role of TGR5 in cell proliferation. Strong TGR5 staining was present in 12% of cases of intestinal metaplasia but in no cases of normal gastric epithelium (P < 0.01). Moderate to strong TGR5 membranous and cytoplasmic staining was present in 52% of the intestinal but in only 25% of the diffuse subtype of adenocarcinomas (P < 0.001). Kaplan-Meier univariate survival analysis revealed that moderate to strong TGR5 staining was associated with decreased patient survival (P < 0.05). Treatment with taurodeoxycholic acid (TDCA, a bile acid) significantly increased thymidine incorporation in the AGS gastric adenocarcinoma cell line, suggesting that bile acids may increase cell proliferation. This increase was significantly decreased by knockdown of TGR5 with TGR5 small-interfering RNA (siRNA). In addition, overexpression of TGR5 significantly enhanced TDCA-induced increases in thymidine incorporation. TGR5 is coupled with G(q)α and Gα(i-3) proteins. TDCA-induced increase in thymidine incorporation was significantly decreased by knockdown of G(q)α and Gα(i-3) with their siRNAs. We conclude that TGR5 is overexpressed in most gastric intestinal-type adenocarcinomas, and moderate to strong TGR5 staining is associated with decreased patient survival in all gastric adenocarcinomas. Bile acids increase cell proliferation via activation of TGR5 receptors and G(q)α and Gα(i-3) proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.