ArticleMolecular biology reports2013
Heat stress-induced BBX18 negatively regulates the thermotolerance in Arabidopsis.
Article in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 96 citations in OpenAlex.
- Evolutionary and functional characterization of BBX genes in the barley pangenome.BMC plant biology · 2026Article
- Genome-Wide Identification of the Double B-Box (DBB) Family in Three Cotton Species and Functional Analysis ofPlants (Basel, Switzerland) · 2025Article
- Genome-wide identification of BBX gene family and its function in defense of necrotrophic fungus Alternaria sp. in Chrysanthemum.BMC genomics · 2025Article
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- The BBX family and their response to abiotic stress in ginger (Zingiber officinale Roscoe).BMC genomics · 2025Article
- Transcript-Wide Identification and Characterization of the BBX Gene Family inPlants (Basel, Switzerland) · 2025Article
- More than flowering: CONSTANS plays multifaceted roles in plant development and stress responses.Journal of integrative plant biology · 2025Review
- Identification of the BBX gene family in blueberry at different chromosome ploidy levels and fruit development and response under stress.BMC genomics · 2025Article
- Genome-Wide Identification, Characterization and Expression Patterns of the DBB Transcription Factor Family Genes in Wheat.International journal of molecular sciences · 2024Article
- A truncated B-box zinc finger transcription factor confers drought sensitivity in modern cultivated tomatoes.Nature communications · 2024Article
- Elucidating the Role ofInternational journal of molecular sciences · 2024Article
- In silico analysis of the wheat BBX gene family and identification of candidate genes for seed dormancy and germination.BMC plant biology · 2024Article
- Article
- Characterization and expression profiles of the B-box gene family during plant growth and under low-nitrogen stress in Saccharum.BMC genomics · 2023Article
- Multi-layered roles of BBX proteins in plant growth and development.Stress biology · 2023Review
- The Function ofGenes · 2022Article
- Transcriptomic Analysis Reveals the Correlation between End-of-Day Far Red Light and Chilling Stress inGenes · 2022Article
- Rice and3 Biotech · 2022Review
- Chromosome-level genome assembly and characterization of Sophora Japonica.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- BBX16 mediates the repression of seedling photomorphogenesis downstream of the GUN1/GLK1 module during retrograde signalling.The New phytologist · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing evidence for considerable interlinking between the responses to heat stress (HS) and light signaling. In the present work, we provide molecular evidence that BBX18, a negative regulator in photomorphogenesis belonging to the B-box zinc finger protein family in Arabidopsis thaliana, is involved in the regulation of thermotolerance. Using quantitative RT-PCR, GUS staining and immunoblot analysis, our results indicate that the expression of BBX18 was induced by HS. BBX18-RNAi and 35S::BBX18 transgenic Arabidopsis plants were obtained for functional analysis of BBX18. Under-expression of BBX18 displayed increased both basal and acquired thermotolerance in the transgenic plants, while over-expression of BBX18 reduced tolerance to HS in transgenic lines. Moreover, when wild-type, BBX18-RNAi and 35S::BBX18 transgenic plants were treated with HS, HR-related digalactosyldiacylglycerol synthase 1 (DGD1) was down-regulated by BBX18 in both normal and heat shock conditions. Besides, the expression levels of Hsp70, Hsp101 and APX2 were increased in BBX18-RNAi transgenic plants, but lower in 35S::BBX18 transgenic plants. However, the expression of HsfA2 was lower in BBX18-RNAi transgenic plants and higher in the 35S::BBX18 after high-temperature treatment. These results suggesting that, by modulated expression of a set of HS-responsive genes, BBX18 weakened tolerance to HS in Arabidopsis. So our data indicate that BBX18 plays a negative role in thermotolerance.
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