ArticleThe Journal of comparative neurology2013
Neurogenesis is required for behavioral recovery after injury in the visual system of Xenopus laevis.
Article in The Journal of comparative neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Assessing circuit function in the developingFrontiers in behavioral neuroscience · 2026Review
- TheFrontiers in medicine · 2025Review
- X-Tracker: Automated Analysis of Xenopus Tadpole Visual Avoidance Behavior.bioRxiv : the preprint server for biology · 2024Article
- Visual input regulates melanophore differentiation.Frontiers in cell and developmental biology · 2024Article
- A Focal Impact Model of Traumatic Brain Injury inInternational journal of molecular sciences · 2022Article
- Temporal and spatial transcriptomic dynamics across brain development in Xenopus laevis tadpoles.G3 (Bethesda, Md.) · 2022Article
- An Innate Color Preference Displayed byFrontiers in behavioral neuroscience · 2020Article
- Nutrient restriction causes reversible G2 arrest inDevelopment (Cambridge, England) · 2019Article
- A Comparative Perspective on Brain Regeneration in Amphibians and Teleost Fish.Developmental neurobiology · 2019Review
- Enhanced visual experience rehabilitates the injured brain in Xenopus tadpoles in an NMDAR-dependent manner.Journal of neurophysiology · 2019Article
- Direct intertectal inputs are an integral component of the bilateral sensorimotor circuit for behavior in Xenopus tadpoles.Journal of neurophysiology · 2018Article
- Reversible developmental stasis in response to nutrient availability in the Xenopus laevis central nervous system.The Journal of experimental biology · 2017Article
- Spinal cord regeneration in Xenopus laevis.Nature protocols · 2017Article
- Pattern of Neurogenesis and Identification of Neuronal Progenitor Subtypes during Pallial Development inFrontiers in neuroanatomy · 2017Article
- Color and intensity discrimination in Xenopus laevis tadpoles.Animal cognition · 2016Article
- Fragile X Mental Retardation Protein Is Required to Maintain Visual Conditioning-Induced Behavioral Plasticity by Limiting Local Protein Synthesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- HDAC3 But not HDAC2 Mediates Visual Experience-Dependent Radial Glia Proliferation in the DevelopingFrontiers in cellular neuroscience · 2016Article
- HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum.PloS one · 2015Article
- Modeling human neurodevelopmental disorders in the Xenopus tadpole: from mechanisms to therapeutic targets.Disease models & mechanisms · 2013Review
- Hypoxia-Responsive Subtype Cells Differentiate Into Neurons in the Brain of Zebrafish Embryos Exposed to Hypoxic Stress.Cell transplantationArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Nonmammalian vertebrates have a remarkable capacity to regenerate brain tissue in response to central nervous system (CNS) injury. Nevertheless, it is not clear whether animals recover lost function after injury or whether injury-induced cell proliferation mediates recovery. We address these questions using the visual system and visually-guided behavior in Xenopus laevis tadpoles. We established a reproducible means to produce a unilateral focal injury to optic tectal neurons without damaging retinotectal axons. We then assayed a tectally-mediated visual avoidance behavior to evaluate behavioral impairment and recovery. Focal ablation of part of the optic tectum prevents the visual avoidance response to moving stimuli. Animals recover the behavior over the week following injury. Injury induces a burst of proliferation of tectal progenitor cells based on phospho-histone H3 immunolabeling and experiments showing that Musashi-immunoreactive tectal progenitors incorporate the thymidine analog chlorodeoxyuridine after injury. Pulse chase experiments indicate that the newly-generated cells differentiate into N-β-tubulin-immunoreactive neurons. Furthermore, in vivo time-lapse imaging shows that Sox2-expressing neural progenitors divide in response to injury and generate neurons with elaborate dendritic arbors. These experiments indicate that new neurons are generated in response to injury. To test if neurogenesis is necessary for recovery from injury, we blocked cell proliferation in vivo and found that recovery of the visual avoidance behavior is inhibited by drugs that block cell proliferation. Moreover, behavioral recovery is facilitated by changes in visual experience that increase tectal progenitor cell proliferation. Our data indicate that neurogenesis in the optic tectum is critical for recovery of visually-guided behavior after injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.