ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2013
Absence of inflammatory conditions in human varicose saphenous veins.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Decreased PGE₂ content reduces MMP-1 activity and consequently increases collagen density in human varicose vein.PloS one · 2014Trial
- Review
- The Impact of Inflammatory Markers and Obesity in Chronic Venous Disease.Biomedicines · 2024Article
- Utility of routine laboratory tests in the assessment of chronic venous disease progression in female patients.Experimental and therapeutic medicine · 2022Article
- Inflammation increases MMP levels via PGEInternational journal of obesity (2005) · 2019Article
- Reverse Regulatory Pathway (H2S / PGE2 / MMP) in Human Aortic Aneurysm and Saphenous Vein Varicosity.PloS one · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVaricose veins affect one-third of the adult population in western countries, but their pathogenesis is incompletely characterized. One of the most controversial issues is the role of inflammation. It is well known that inflammation involves an increased expression/activity of inflammatory mediators.
objectiveThe aim of this study was to investigate the presence or absence of mediators of inflammation in varicose as compared to healthy veins. METHODS AND
resultsUsing immunohistofluorescence on varicose and healthy veins, we investigated the presence of inflammatory cells. They were not detectable. Venous wall C-reactive protein (CRP), fibrinogen (EIA) and pentraxin-3 (Western blot) content were measured. CRP was significantly lower in varicose veins, but no difference was found for fibrinogen or pentraxin-3 between varicose and healthy veins. No difference was observed for enzymes involved in inflammation and responsible for arachidonic acid metabolism such as the acute phase reactant secreted phospholipase A₂-IIA and cyclooxygenase-2, as determined in varicose and healthy veins by Western blot and real-time qRT-PCR.
conclusionsOur experiments demonstrate no increase in the presence of mediators of inflammation in varicose as compared to healthy veins, suggesting that inflammation may not be an important contributor to the pathogenesis of varicose veins.
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Registered trials
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