ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
The laminar development of direction selectivity in ferret visual cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Early Development of Direction Selectivity in the Higher Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Impact of Acute Visual Experience on Development of LGN Receptive Fields in the Ferret.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Balanced Enhancements of Synaptic Excitation and Inhibition Underlie Developmental Maturation of Receptive Fields in the Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Synaptic and intrinsic mechanisms underlying development of cortical direction selectivity.eLife · 2020Article
- Article
- Ferrets as a Model for Higher-Level Visual Motion Processing.Current biology : CB · 2019Article
- Discrimination of Motion Direction in a Robot Using a Phenomenological Model of Synaptic Plasticity.Computational intelligence and neuroscience · 2019Article
- Development of Cross-Orientation Suppression and Size Tuning and the Role of Experience.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Optogenetic spatial and temporal control of cortical circuits on a columnar scale.Journal of neurophysiology · 2016Article
- A Computational Model of Innate Directional Selectivity Refined by Visual Experience.Scientific reports · 2015Article
- Weak orientation and direction selectivity in lateral geniculate nucleus representing central vision in the gray squirrel Sciurus carolinensis.Journal of neurophysiology · 2015Article
- Layer-specific refinement of visual cortex function after eye opening in the awake mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The development of cortical circuits for motion discrimination.Nature neuroscience · 2015Article
- Emerging feed-forward inhibition allows the robust formation of direction selectivity in the developing ferret visual cortex.Journal of neurophysiology · 2014Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Sensory experience plays a critical role in the development of cortical circuits. At the time of eye opening, visual cortical neurons in the ferret exhibit orientation selectivity, but lack direction selectivity, which is a feature of mature cortical neurons in this species. Direction selectivity emerges in the days and weeks following eye opening via a process that requires visual experience. However, the circuit mechanisms that underlie the development of direction selectivity remain unclear. Here, we used microelectrodes to examine the laminar chronology of the development of direction selectivity around the time of eye opening to identify the locations within the cortical circuit that are altered during this process. We found that neurons in layers 4 and 2/3 exhibited weak direction selectivity just before natural eye opening. Layer 4 neurons in animals that had opened their eyes but were younger than postnatal day 35 (PND 35) exhibited modestly increased direction selectivity, but layer 2/3 cells remained as weakly tuned as before eye opening. Animals that had opened their eyes and were PND 35 or older exhibited increased direction selectivity in both layers 4 and 2/3. On average, initial increases in direction selectivity in animals younger than PND 35 were explained by increases in responses to the preferred direction, while subsequent increases in direction selectivity in animals PND 35 or older were explained by decreases in responses to the null direction. These results suggest that all cortical layers are influenced by sensory stimulation during early stages of experience-dependent development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.