ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Generation of intensity selectivity by differential synaptic tuning: fast-saturating excitation but slow-saturating inhibition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Auditory fear conditioning alters neural gain in the cochlear nucleus: a wireless neural recording study in freely behaving rats.Neuronal signaling · 2020Article
- Age-related changes in sound onset and offset intensity coding in auditory cortical fields A1 and CL of rhesus macaques.Journal of neurophysiology · 2020Article
- Robust and Intensity-Dependent Synaptic Inhibition Underlies the Generation of Non-monotonic Neurons in the Mouse Inferior Colliculus.Frontiers in cellular neuroscience · 2019Article
- A Non-canonical Reticular-Limbic Central Auditory Pathway via Medial Septum Contributes to Fear Conditioning.Neuron · 2018Article
- Article
- Serotonergic Modulation of Sensory Representation in a Central Multisensory Circuit Is Pathway Specific.Cell reports · 2017Article
- Dynamic balance of excitation and inhibition rapidly modulates spike probability and precision in feed-forward hippocampal circuits.Journal of neurophysiology · 2016Article
- Synaptic Basis for the Generation of Response Variation in Auditory Cortex.Scientific reports · 2016Article
- The Functional Networks of Prepulse Inhibition: Neuronal Connectivity Analysis Based on FDG-PET in Awake and Unrestrained Rats.Frontiers in behavioral neuroscience · 2016Article
- Dorsal Cochlear Nucleus of the Rat: Representation of Complex Sounds in Ears Damaged by Acoustic Trauma.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
- A model for non-monotonic intensity coding.Royal Society open science · 2015Article
- Balance or imbalance: inhibitory circuits for direction selectivity in the auditory system.Cellular and molecular life sciences : CMLS · 2015Review
- Synaptic mechanisms for generating temporal diversity of auditory representation in the dorsal cochlear nucleus.Journal of neurophysiology · 2015Article
- Stimulus-timing-dependent modifications of rate-level functions in animals with and without tinnitus.Journal of neurophysiology · 2015Article
- Functional dissection of synaptic circuits: in vivo patch-clamp recording in neuroscience.Frontiers in neural circuits · 2015Review
- Functional response properties of VIP-expressing inhibitory neurons in mouse visual and auditory cortex.Frontiers in neural circuits · 2015Article
- Control of interneuron firing by subthreshold synaptic potentials in principal cells of the dorsal cochlear nucleus.Neuron · 2014Article
- Thresholding of auditory cortical representation by background noise.Frontiers in neural circuits · 2014Article
- Cell-type specific short-term plasticity at auditory nerve synapses controls feed-forward inhibition in the dorsal cochlear nucleus.Frontiers in neural circuits · 2014Article
- Nonlinear temporal receptive fields of neurons in the dorsal cochlear nucleus.Journal of neurophysiology · 2013Article
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Intensity defines one fundamental aspect of sensory information and is specifically represented in each sensory modality. Interestingly, only in the central auditory system are intensity-selective neurons evolved. These neurons are characterized by nonmonotonic response-level functions. The synaptic circuitry mechanisms underlying the generation of intensity selectivity from nonselective auditory nerve inputs remain largely unclear. Here, we performed in vivo whole-cell recordings from pyramidal neurons in the rat dorsal cochlear nucleus (DCN), where intensity selectivity first emerges along the auditory neuraxis. Our results revealed that intensity-selective cells received fast-saturating excitation but slow-saturating inhibition with intensity increments, whereas in intensity-nonselective cells excitation and inhibition were similarly slow-saturating. The differential intensity tuning profiles of the monotonic excitation and inhibition qualitatively determined the intensity selectivity of output responses. In addition, the selectivity was further strengthened by significantly lower excitation/inhibition ratios at high-intensity levels compared with intensity-nonselective neurons. Our results demonstrate that intensity selectivity in the DCN is generated by extracting the difference between tuning profiles of nonselective excitatory and inhibitory inputs, which we propose can be achieved through a differential circuit mediated by feedforward inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.