ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Identification and characterization of a sleep-active cell group in the rostral medullary brainstem.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 111 citations in OpenAlex.
- The sleep-wake cycle: molecular mechanisms, disorders, and therapeutic targets in the context of energy metabolism.Signal transduction and targeted therapy · 2026Review
- Cerebellar Electrical Activity as a Marker for Predicting Brain Health and Disease: A Review.Brain sciences · 2026Review
- Homeostatic coupling of cortical and brainstem delta rhythms in sleeping infant rats.bioRxiv : the preprint server for biology · 2026Article
- Parafacial GABAergic neurone ablation induces behavioural resistance to volatile anaesthetic-induced hypnosis without reducing sleep.British journal of anaesthesia · 2025Article
- Adenosine-Dependent Arousal Induced by Astrocytes in a Brainstem Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Role of the Locus Coeruleus Arousal Promoting Neurons in Maintaining Brain Criticality across the Sleep-Wake Cycle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Coincident development and synchronization of sleep-dependent delta in the cortex and medulla.Current biology : CB · 2024Article
- DELTA-RHYTHMIC ACTIVITY IN THE MEDULLA DEVELOPS COINCIDENT WITH CORTICAL DELTA IN SLEEPING INFANT RATS.bioRxiv : the preprint server for biology · 2024Article
- A novel GABAergic population in the medial vestibular nucleus maintains wakefulness and gates rapid eye movement sleep.iScience · 2024Article
- Article
- Tfap2b acts in GABAergic neurons to control sleep in mice.Scientific reports · 2023Article
- Simultaneous Microendoscopic Calcium Imaging and EEG Recording of Mouse Brain during Sleep.Bio-protocol · 2023Article
- Article
- Potential interactions between cerebellar dysfunction and sleep disturbances in dystonia.Dystonia (Lausanne, Switzerland) · 2022Article
- An excitatory peri-tegmental reticular nucleus circuit for wake maintenance.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area.Nature communications · 2022Article
- The Sleep-Promoting Ventrolateral Preoptic Nucleus: What Have We Learned over the Past 25 Years?International journal of molecular sciences · 2022Review
- Cerebellar malfunction and postoperative sleep disturbances after general anesthesia: a narrative review.Sleep & breathing = Schlaf & Atmung · 2022Review
- Sex Hormones, Sleep, and Memory: Interrelationships Across the Adult Female Lifespan.Frontiers in aging neuroscience · 2022Review
- The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice.Current biology : CB · 2021Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Early transection and stimulation studies suggested the existence of sleep-promoting circuitry in the medullary brainstem, yet the location and identity of the neurons comprising this putative hypnogenic circuitry remains unresolved. In the present study, we sought to uncover the location and identity of medullary neurons that might contribute to the regulation of sleep. Here we show the following in rats: (1) a delimited node of medullary neurons located lateral and dorsal to the facial nerve-a region we termed the parafacial zone (PZ)-project to the wake-promoting medial parabrachial nucleus; (2) PZ neurons express c-Fos after sleep but not after wakefulness and hence are sleep active; and (3) cell-body-specific lesions of the PZ result in large and sustained increases (50%) in daily wakefulness at the expense of slow-wave sleep (SWS). Using transgenic reporter mice [vesicular GABA/glycine transporter (Vgat)-GFP], we then show that >50% of PZ sleep-active neurons are inhibitory (GABAergic/glycinergic, VGAT-positive) in nature. Finally, we used a Cre-expressing adeno-associated viral vector and conditional Vgat(lox/lox) mice to selectively and genetically disrupt GABA/glycinergic neurotransmission from PZ neurons. Disruption of PZ GABAergic/glycinergic neurotransmission resulted in sustained increases (40%) in daily wakefulness at the expense of both SWS and rapid eye movement sleep. These results together reveal the location and neurochemical identity of a delimited node of sleep-active neurons within the rostral medullary brainstem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.