Evidence map›Paper›PMID 23238293›Full record

Trial reportDiabetes2013

A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.

C Lawrence Kien, Janice Y Bunn, Matthew E Poynter, Robert Stevens, James Bain, Olga Ikayeva, Naomi K Fukagawa, Catherine M Champagne, Karen I Crain, Timothy R Koves and 1 more

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 71 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01612234 nacompletednot on this map

Palmitate Metabolism and Insulin Resistance

TypeinterventionalSponsorUniversity of VermontRan2010 to 2015Enrolled70ConditionsObesityArmsHigh palmitate or high oleate diet.
NCT03577119 nacompletednot on this mapstarted 2018, after this paper: background citation

Full-fat Yogurt and Glucose Tolerance

TypeinterventionalSponsorUniversity of Vermont Medical CenterRan2018 to 2022Enrolled13ConditionsPre-DiabetesArmsFull-fat yogurt, Non-fat yogurt
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 134 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

C Lawrence KienDepartment of Pediatrics, University of Vermont, Burlington, Vermont, USA. cl.kien@uvm.edu
Janice Y Bunn
Matthew E Poynter
Robert Stevens
James Bain
Olga Ikayeva
Naomi K Fukagawa
Catherine M Champagne
Karen I Crain
Timothy R Koves
Deborah M Muoio
Duke University · USUniversity of Vermont · USPennington Biomedical Research Center · USUniversity of Vermont Medical Center · US

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
WEIGHT MAINTENANCE AND PSYCHOLOGICAL BENEFITS OF EXERCISEM01RR000109 · NCRR · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI DUMAS, JULIE A · 1985 to 2010
$24.3M
Palmitate Metabolism and Insulin ResistanceR01DK082803 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KIEN, CRAIG LAWRENCE · 2010 to 2013
$2.1M
Mechanisms for differential effects of dietary fatty acids on metabolismR01DK073284 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KIEN, CRAIG LAWRENCE · 2007 to 2010
$2.1M
NCRR NIH HHS M01 RR000109NCRR NIH HHS RR-00109NIA NIH HHS P30 AG028716NIDDK NIH HHS R01 DK073284NIDDK NIH HHS R01-DK-073284NIDDK NIH HHS R01 DK082803NIDDK NIH HHS R01-DK-082803
6 · The paper itself

Abstract

Relative to diets enriched in palmitic acid (PA), diets rich in oleic acid (OA) are associated with reduced risk of type 2 diabetes. To gain insight into mechanisms underlying these observations, we applied comprehensive lipidomic profiling to specimens collected from healthy adults enrolled in a randomized, crossover trial comparing a high-PA diet to a low-PA/high-OA (HOA) diet. Effects on insulin sensitivity (SI) and disposition index (DI) were assessed by intravenous glucose tolerance testing. In women, but not men, SI and DI were higher during HOA. The effect of HOA on SI correlated positively with physical fitness upon enrollment. Principal components analysis of either fasted or fed-state metabolites identified one factor affected by diet and heavily weighted by the PA/OA ratio of serum and muscle lipids. In women, this factor correlated inversely with SI in the fasted and fed states. Medium-chain acylcarnitines emerged as strong negative correlates of SI, and the HOA diet was accompanied by lower serum and muscle ceramide concentrations and reductions in molecular biomarkers of inflammatory and oxidative stress. This study provides evidence that the dietary PA/OA ratio impacts diabetes risk in women.

Indexed as

Insulin ResistanceAdolescentAdultAgingBody CompositionCohort StudiesCross-Over StudiesDietDietary FatsFemaleFood AnalysisHumansLipid MetabolismMaleMotor ActivityOleic AcidDietary FatsOleic AcidPalmitic Acid

Identifiers

PMID23238293
PMCPMC3609566
OpenAlexW2144946248

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.