ArticleInfection and immunity1990
Cross-reactivity and sequence homology between the 65-kilodalton mycobacterial heat shock protein and human lactoferrin, transferrin, and DR beta subsets of major histocompatibility complex class II molecules.
Article in Infection and immunity, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 70 citations in OpenAlex.
- Immune dysregulation and pathogenic pathways mediated by common infections in rheumatoid arthritis.Folia microbiologica · 2023Review
- Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria.Microorganisms · 2020Review
- Cellular and humoral mechanisms involved in the control of tuberculosis.Clinical & developmental immunology · 2012Review
- Humoral immunity in tuberculin skin test anergy and its role in high-risk persons exposed to active tuberculosis.Molecular immunology · 2010Article
- CC chemokine receptor (CCR)-2 prevents arthritis development following infection by Mycobacterium avium.Journal of molecular medicine (Berlin, Germany) · 2006Article
- Detection of Mycobacterium tuberculosis group organisms in human and mouse joint tissue by reverse transcriptase PCR: prevalence in diseased synovial tissue suggests lack of specific association with rheumatoid arthritis.Infection and immunity · 2001Article
- Are anti-neutrophil cytoplasmic antibodies (ANCA) clinically useful in inflammatory bowel disease (IBD)?Clinical and experimental immunology · 1999Review
- A role for CD45RBlow CD38+ T cells and costimulatory pathways of T-cell activation in protection of non-obese diabetic (NOD) mice from diabetes.Immunology · 1999Article
- Mechanisms of Mycobacterium avium-induced resistance against insulin-dependent diabetes mellitus (IDDM) in non-obese diabetic (NOD) mice: role of Fas and Th1 cells.Clinical and experimental immunology · 1999Article
- Growth within macrophages increases the efficiency of Mycobacterium avium in invading other macrophages by a complement receptor-independent pathway.Infection and immunity · 1997Article
- Diabetes-prone NOD mice are resistant to Mycobacterium avium and the infection prevents autoimmune disease.Immunology · 1996Article
- Article
- Stress modulates acute inflammation triggered by mycobacteria in autoimmunity-prone and normal mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 1995Article
- Antibody to mycobacterial 65-kD heat shock protein in commercial antisera.Clinical and experimental immunology · 1993Article
- Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.The American journal of pathology · 1993Article
- Mycobacterial 65,000 MW heat-shock protein shares a carboxy-terminal epitope with human epidermal cytokeratin 1/2.Immunology · 1992Article
- The humoral immune response to heat shock proteins.Experientia · 1992Review
- Variable gene usage of T cell receptor gamma- and delta-chain transcripts expressed in synovia and peripheral blood of patients with rheumatoid arthritis.Clinical and experimental immunology · 1992Article
- Mycobacteria and human autoimmune disease: direct evidence of cross-reactivity between human lactoferrin and the 65-kilodalton protein of tubercle and leprosy bacilli.Infection and immunity · 1991Article
- Heat-shock proteins, and gamma alpha/delta T cells.Springer seminars in immunopathology · 1991Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunogold ultracytochemistry and Western immunoblotting showed that polyclonal antibodies against human lactoferrin bind to the highly immunogenic 65-kilodalton (kDa) heat shock protein of mycobacteria. The fast-growing mycobacterial species Mycobacterium smegmatis showed a higher density of these receptors for antilactoferrin sera than the slow-growing M. avium. Polyclonal antibodies against mycobacteria (M. bovis BCG) recognized human lactoferrin. Comparison of the amino acid sequence of lactoferrin with that of the 65-kDa protein of M. tuberculosis revealed seven instances of four amino acid sequence homology between the microbial and the human iron-binding protein. Four of these tetrapeptide sequences were also shared with the human transferrin molecule. The shared amino acid sequence KDLL was also present in the DR1, DR3, and DR4 subsets of the DR beta subregion of major histocompatibility complex (MHC) class II molecules. The molecular mimicry between the 65-kDa mycobacterial protein and the human proteins (lactoferrin, transferrin, and MHC class II molecules) offers a molecular setting for mycobacteria-associated, T-cell-dependent autoimmune disease, namely, for rheumatoid arthritis.
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