Evidence map›Paper›PMID 23238227›Full record

ArticleNuclear medicine communications2013

Left-ventricular dyssynchrony evaluated by Tl-201 gated SPECT myocardial perfusion imaging: a comparison with Tc-99m sestamibi.

Chien-Cheng Chen, Wen-Sheng Huang, Guang-Uei Hung, Wan-Chen Chen, Chia-Hung Kao, Ji Chen

Open access · greenAbstract readComparative Study
In one paragraph

Article in Nuclear medicine communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Mechanical dyssynchrony according to validated cut-off values using gated SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  4. Optimal thallium-201 dose in cadmium-zinc-telluride SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  5. Article
  6. Article
  7. Observational
  8. Review
  9. Cut-off values of myocardial perfusion gated-SPECT phase analysis parameters of normal subjects, and conduction and mechanical cardiac diseases.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015
    Article
  10. Does perfusion pattern influence stress-induced changes in left ventricular mechanical dyssynchrony on thallium-201-gated SPECT myocardial perfusion imaging?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015
    Article
  11. Relation of early post-stress left ventricular dyssynchrony and the extent of angiographic coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014
    Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Chien-Cheng ChenDepartment of Cardiology, Show Chwan Memorial Hospital, Changhua, Taiwan.
Wen-Sheng Huang
Guang-Uei Hung
Wan-Chen Chen
Chia-Hung Kao
Ji Chen
Chang Bing Show Chwan Memorial Hospital · TWChanghua Christian Hospital · TWChina Medical University · TWEmory University · US

Funding

Measuring Left Ventricular Dyssynchrony from ECG-gated Myocardial Perfusion SPECTR01HL094438 · NHLBI · EMORY UNIVERSITY · PI CHEN, JI · 2009 to 2012
$1.5M
NHLBI NIH HHS 1R01HL094438NHLBI NIH HHS R01 HL094438
6 · The paper itself

Abstract

background and purposePhase analysis of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) has been validated as a reliable tool to assess left-ventricular (LV) mechanical dyssynchrony. The initial results were all confirmed from studies using technetium-99m (Tc-99m) sestamibi or tetrofosmin as the radiotracers. The purpose of this study was to evaluate the feasibility of phase analysis in thallium-201 (Tl-201) gated SPECT MPI. MATERIALS AND

methodsSeventeen patients referred from a cardiology clinic for evaluation of coronary artery disease were studied. All patients underwent both Tl-201 and Tc-99m sestamibi gated SPECT MPI within 1 week. An additional 34 patients with Tl-201 gated SPECT and 22 patients with Tc-99m sestamibi gated SPECT, who had a low likelihood of coronary artery disease, normal LV function, and normal perfusion on MPI, were used as normal controls. LV dyssynchrony parameters, including phase standard deviation (PSD) and phase histogram bandwidth (PHB), were measured using a standard phase analysis tool and compared between Tl-201 and Tc-99m sestamibi images.

resultsThe LV dyssynchrony parameters correlated well (r=0.93 for PSD and r=0.84 for PHB) between Tl-201 and Tc-99m sestamibi images. The dyssynchrony parameters of Tl-201 were significantly larger than those of Tc-99m sestamibi (PSD: 24.5±12.0 vs. 17.4±9.7, P<0.001; PHB: 74.7±35.5 vs. 50.6±25.0, P<0.001). In comparison with normal controls, Tl-201 and Tc-99m sestamibi images showed concordant results.

conclusionLV dyssynchrony parameters correlated well between Tl-201 and Tc-99m sestamibi images, even though the values were significantly larger for Tl-201 than for Tc-99m sestamibi. Tl-201 images showed results similar to those of Tc-99m sestamibi in the diagnosis of LV dyssynchrony.

Indexed as

Myocardial Perfusion ImagingRadiopharmaceuticalsTechnetium Tc 99m SestamibiThallium RadioisotopesAdultAgedCardiac Resynchronization TherapyCoronary Artery DiseaseFemaleHumansMaleMiddle AgedProhibitinsReproducibility of ResultsTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftPHB protein, humanProhibitinsRadiopharmaceuticalsTechnetium Tc 99m SestamibiThallium Radioisotopes

Identifiers

PMID23238227
PMCPMC3731541
OpenAlexW2003733859

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.