Evidence map›Paper›PMID 2323822›Full record

ArticleInfection and immunity1990

Production, characterization, and species specificity of monoclonal antibodies to Mycobacterium avium complex protein antigens.

D A Rouse, S L Morris, A B Karpas, P G Probst, S D Chaparas

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

D A RouseCenter for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892.
S L Morris
A B Karpas
P G Probst
S D Chaparas
Center for Biologics Evaluation and Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of Mycobacterium avium-Mycobacterium intracellulare complex infections has increased in recent years primarily because a significant proportion of acquired immunodeficiency syndrome patients develop disseminated M. avium complex disease. In an effort to develop new tools to study these infections, we have produced eight monoclonal antibodies directed against M. avium. Western blot (immunoblot) specificity analysis and protease sensitivity assays indicate that four of these antibodies recognize M. avium-specific protein epitopes and two react with M. avium complex-specific peptide determinants. These monoclonal antibodies may be useful clinically in the diagnosis of M. avium complex disease and in the laboratory for isolation and characterization of native and recombinant M. avium complex antigens.

Indexed as

Acquired Immunodeficiency SyndromeAntibodies, BacterialAntibodies, MonoclonalAntibody SpecificityAntigens, BacterialBacterial ProteinsBlotting, WesternCross ReactionsHumansImmunoglobulin IsotypesMolecular WeightMycobacterium avium ComplexSpecies SpecificityAntibodies, BacterialAntibodies, MonoclonalAntigens, BacterialBacterial ProteinsImmunoglobulin Isotypes

Identifiers

PMID2323822
PMCPMC258645
OpenAlexW2413217857

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.