ArticleClinical and translational gastroenterology2012
Elevated Tumor Expression of PAI-1 and SNAI2 in Obese Esophageal Adenocarcinoma Patients and Impact on Prognosis.
Article in Clinical and translational gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis.Oncotarget · 2017Pooled it
- Climate Change and the Esophagus: Speculations on Changing Disease Patterns as the World Warms.Current gastroenterology reports · 2023Review
- Obesity and cancer stem cells: Roles in cancer initiation, progression and therapy resistance.World journal of stem cells · 2023Review
- Visceral Obesity, Metabolic Syndrome, and Esophageal Adenocarcinoma.Frontiers in oncology · 2021Review
- Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma.International journal of medical sciences · 2019Article
- Obesity and gastrointestinal cancer: the interrelationship of adipose and tumour microenvironments.Nature reviews. Gastroenterology & hepatology · 2018Review
- Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence.Oncotarget · 2015Article
- Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma.BMC cancer · 2014Article
- Expression of Bmi-1 and PAI-1 in esophageal squamous cell carcinoma.World journal of gastroenterology · 2014Article
- Re: Overweight patients achieve ideal body weight following curative gastrectomy resulting in better long-term prognosis.Obesity surgery · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesObesity is linked to increased mortality from many cancer types, and esophageal adenocarcinoma (EAC) displays one of the strongest epidemiological associations. The aims of this study are to dissect molecular pathways linking obesity with EAC and to determine if obesity is linked to increased aggressiveness of this disease.
methodsAffymetrix microarrays identified altered signaling pathways in an EAC cell line following coculture with visceral adipose tissue or isolated adipocytes from viscerally obese EAC patients (n=6). Differentially expressed genes were subsequently investigated in patient tumor biopsies by quantitative reverse transcriptase PCR and examined with respect to obesity status, tumor biology, and patient survival.
resultsVisceral adipose tissue induced expression of genes involved in epithelial mesenchymal transition (EMT), plasminogen activator inhibitor (PAI)-1, and transcription factor SNAI2, in an EAC cell line. In EAC patient tumor biopsies from obese patients, we noted elevated expression of these genes, together with reduced expression of epithelial marker E-cadherin. SNAI2 was associated with EAC prognosis.
conclusionsExpression of EMT genes, PAI-1 and SNAI2, was elevated in tumors of obese EAC patients, and SNAI2 was associated with poor survival. Genes deregulated in obesity and associated with prognosis may represent potential targets for treatment stratification of obese EAC patients.
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Registered trials
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