ArticleNeurotoxicology and teratology
Children with heavy prenatal alcohol exposure have different frequency domain signal characteristics when producing isometric force.
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Spiral drawing deficits in children with prenatal alcohol exposure.Alcohol, clinical & experimental research · 2023Article
- Children with Heavy Prenatal Alcohol Exposure Exhibit Atypical Gait Characteristics.Alcoholism, clinical and experimental research · 2017Article
- Ifenprodil infusion in agranular insular cortex alters social behavior and vocalizations in rats exposed to moderate levels of ethanol during prenatal development.Behavioural brain research · 2017Article
- Moderate Maternal Alcohol Exposure on Gestational Day 12 Impacts Anxiety-Like Behavior in Offspring.Frontiers in behavioral neuroscience · 2017Article
- Effects of sex and housing on social, spatial, and motor behavior in adult rats exposed to moderate levels of alcohol during prenatal development.Behavioural brain research · 2016Article
- Article
- Importance of genetics in fetal alcohol effects: null mutation of the nNOS gene worsens alcohol-induced cerebellar neuronal losses and behavioral deficits.Neurotoxicology · 2015Article
- Effects of moderate prenatal ethanol exposure and age on social behavior, spatial response perseveration errors and motor behavior.Behavioural brain research · 2014Article
- Automated cerebellar segmentation: Validation and application to detect smaller volumes in children prenatally exposed to alcohol.NeuroImage. Clinical · 2014Article
- The importance of measurement precision and behavioral homologies in evaluating the behavioral consequences of fetal-ethanol exposure: commentary on Williams and colleagues ("Sensory-motor deficits in children with fetal alcohol spectrum disorder assessed using a robotic virtual reality platform").Alcoholism, clinical and experimental research · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
To extend our current understanding of the teratogenic effects of prenatal alcohol exposure on the control of isometric force, the present study investigated the signal characteristics of power spectral density functions resulting from sustained control of isometric force by children with and without heavy prenatal exposure to alcohol. It was predicted that the functions associated with the force signals would be fundamentally different for the two groups. Twenty-five children aged between 7 and 17 years with heavy prenatal alcohol exposure and 21 non-alcohol exposed control children attempted to duplicate a visually represented target force by pressing on a load cell. The level of target force (5 and 20% of maximum voluntary force) and the time interval between visual feedback (20 ms, 320 ms and 740 ms) were manipulated. A multivariate spectral estimation method with sinusoidal windows was applied to individual isometric force-time signals. Analysis of the resulting power spectral density functions revealed that the alcohol-exposed children had a lower mean frequency, less spectral variability, greater peak power and a lower frequency at which peak power occurred. Furthermore, mean frequency and spectral variability produced by the alcohol-exposed group remained constant across target load and visual feedback interval, suggesting that these children were limited to making long-time scale corrections to the force signal. In contrast, the control group produced decreased mean frequency and spectral variability as target force and the interval between visual feedback increased, indicating that when feedback was frequently presented these children used the information to make short-time scale adjustments to the ongoing force signal. Knowledge of these differences could facilitate the design of motor rehabilitation exercises that specifically target isometric force control deficits in alcohol-exposed children.
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