Evidence map›Paper›PMID 23237943›Full record

ReviewDevelopmental cell2012

Visualizing cell structure and function with point-localization superresolution imaging.

Prabuddha Sengupta, Schuyler Van Engelenburg, Jennifer Lippincott-Schwartz

Abstract readReview
In one paragraph

Review in Developmental cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
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  10. Review
  11. Roles of Gag-RNA interactions in HIV-1 virus assembly deciphered by single-molecule localization microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  12. Article
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  19. HIV-1 assembly, release and maturation.Nature reviews. Microbiology · 2015
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Prabuddha SenguptaCell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Schuyler Van Engelenburg
Jennifer Lippincott-Schwartz

Funding

Organization and Dynamics of Endomembrane Pathways and OrganellesZIAHD001609 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BONIFACINO, JUAN · 2009 to 2019
$16.2M
Development of green fluorescent protein technologyZIAHD008850 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LIPPINCOTT-SCHWARTZ, JENNIFER · 2009 to 2016
$6.5M
Development of green fluorescent protein technologyZ01HD008850 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LIPPINCOTT-SCHWARTZ, JENNIFER · 2007 to 2008
$854k
Intramural NIH HHS Z01 HD008850Intramural NIH HHS Z99 HD999999
6 · The paper itself

Abstract

Fundamental to the success of cell and developmental biology is the ability to tease apart molecular organization in cells and tissues by localizing specific proteins with respect to one another in a native cellular context. However, many key cellular structures (from mitochondrial cristae to nuclear pores) lie below the diffraction limit of visible light, precluding analysis of their organization by conventional approaches. Point-localization superresolution microscopy techniques, such as PALM and STORM, are poised to resolve, with unprecedented clarity, the organizational principles of macromolecular complexes within cells, thus leading to deeper insights into cellular function in both health and disease.

Indexed as

Cell Physiological PhenomenaCellsCellular StructuresFluorescent DyesImaging, Three-DimensionalMicroscopyMicroscopy, FluorescenceMitochondrial MembranesFluorescent Dyes

Identifiers

PMID23237943
PMCPMC4221848

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.