ReviewThe Lancet. Neurology2013
Neuroendocrine considerations in the treatment of men and women with epilepsy.
Review in The Lancet. Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05066360 (Investigation of Serum Antimullerian Hormone Levels in Adolescent Epilepsy Patients), which is not on this map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Serum Antimullerian Hormone Levels in Adolescent Epilepsy Patients
Who cites it
41 citing papers in PubMed, 143 citations in OpenAlex.
- The Neurology of Menopause.Current neurology and neuroscience reports · 2026Review
- Metformin as a Neuroendocrine Modulator in Catamenial Epilepsy: Interplay with Sex Hormones and Neurosteroids.Molecular neurobiology · 2025Review
- Editorial: Steroids and the brain, volume II.Frontiers in endocrinology · 2025Article
- Characterization of the intrahippocampal kainic acid model in female mice with a special focus on seizure suppression by antiseizure medications.Experimental neurology · 2024Article
- Prescription patterns and therapeutic gaps among persons with epilepsy in Southwestern Nigeria.Frontiers in pharmacology · 2024Article
- Relationship between depression and sex steroid hormone among women with epilepsy.Frontiers in neuroscience · 2024Article
- Issues of Women with Epilepsy and Suitable Antiseizure Drugs.Journal of epilepsy research · 2023Review
- Initiation and Duration of Breastfeeding in the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Study.Neurology · 2023Observational
- Article
- Putative roles for homeostatic plasticity in epileptogenesis.Epilepsia · 2023Review
- Sex hormones and risk of epilepsy: A bidirectional Mendelian randomization study.Frontiers in molecular neuroscience · 2023Article
- The Feasibility and Tolerability of Medium Chain Triglycerides in Women with a Catamenial Seizure Pattern on the Modified Atkins Diet.Nutrients · 2021Article
- Reproductive decision-making in families containing multiple individuals with epilepsy.Epilepsia · 2021Article
- Cycles in epilepsy.Nature reviews. Neurology · 2021Review
- Case Report: Hypopituitarism Presenting With Nonconvulsive Status Epilepticus.Frontiers in neurology · 2021Article
- A Clinical Approach to Catamenial Epilepsy: A Review.The Permanente journal · 2020Review
- Article
- Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies.Pharmacological reviews · 2020Review
- Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Metabolome-wide association study of anti-epileptic drug treatment during pregnancy.Toxicology and applied pharmacology · 2019Observational
Corrections and comments
- Erratum issuedDosage error in article text
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Complex, multidirectional interactions between hormones, seizures, and the medications used to control them can present a challenge for clinicians treating patients with epilepsy. Many hormones act as neurosteroids, modulating brain excitability via direct binding sites. Thus, changes in endogenous or exogenous hormone levels can affect the occurrence of seizures directly as well as indirectly through pharmacokinetic effects that alter the concentrations of antiepileptic drugs. The underlying structural and physiological brain abnormalities of epilepsy and the metabolic activity of antiepileptic drugs can adversely affect hypothalamic and gonadal functioning. Knowledge of these complex interactions has increased and can now be incorporated in meaningful treatment approaches for men and women with epilepsy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.