ReviewNeuroscience and biobehavioral reviews2013
The contribution of brain reward circuits to the obesity epidemic.
Review in Neuroscience and biobehavioral reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
132 citing papers in PubMed, 3 syntheses or guidelines pooled it, 278 citations in OpenAlex.
- A Systematic Review of Obesity and Binge Eating Associated Impairment of the Cognitive Inhibition System.Frontiers in nutrition · 2021Pooled it
- The prevalence of food addiction as assessed by the Yale Food Addiction Scale: a systematic review.Nutrients · 2014Pooled it
- Pooled it
- Combination therapy with exenatide decreases the dapagliflozin-induced changes in brain responses to anticipation and consumption of palatable food in patients with type 2 diabetes: A randomized controlled trial.Diabetes, obesity & metabolism · 2022Trial
- Effects of Dapagliflozin and Combination Therapy With Exenatide on Food-Cue Induced Brain Activation in Patients With Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2022Trial
- Dynamic fMRI networks predict success in a behavioral weight loss program among older adults.NeuroImage · 2018Trial
- Pilot test of a novel food response and attention training treatment for obesity: Brain imaging data suggest actions shape valuation.Behaviour research and therapy · 2017Trial
- Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes.Diabetes · 2015Trial
- Emotion, Motivation, Reasoning, and How Their Brain Systems Are Related.Brain sciences · 2025Review
- The BMIgap tool to quantify transdiagnostic brain signatures of current and future weight.Nature. Mental health · 2025Article
- Homeostatic-related peptides injected into the rat nucleus accumbens alter palatable eating and impact the binge-like intake of a sweetened fat diet during simultaneous μ-opioid receptor stimulation.Frontiers in neuroscience · 2025Article
- Review
- Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children.International journal of obesity (2005) · 2024Article
- 5-Methoxy-2-aminoindane Reverses Diet-Induced Obesity and Improves Metabolic Parameters in Mice: A Potential New Class of Antiobesity Therapeutics.ACS pharmacology & translational science · 2024Article
- Obesity- and diet-induced plasticity in systems that control eating and energy balance.Obesity (Silver Spring, Md.) · 2024Review
- The Effect of Unhealthy Food Packaging Information Boundaries on Consumer Purchasing Intentions.Foods (Basel, Switzerland) · 2024Article
- Current perspectives on brain circuits involved in food addiction-like behaviors.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Altered neuronal response to visual food stimuli in adolescents undergoing chronic sleep restriction.Sleep · 2024Article
- Influence of insulin sensitivity on food cue evoked functional brain connectivity in children.bioRxiv : the preprint server for biology · 2024Article
- Effects of junk-food on food-motivated behavior and nucleus accumbens glutamate plasticity; insights into the mechanism of calcium-permeable AMPA receptor recruitment.Neuropharmacology · 2024Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
One of the defining characteristics of the research of Ann E. Kelley was her recognition that the neuroscience underlying basic learning and motivation processes also shed significant light upon mechanisms underlying drug addiction and maladaptive eating patterns. In this review, we examine the parallels that exist in the neural pathways that process both food and drug reward, as determined by recent studies in animal models and human neuroimaging experiments. We discuss contemporary research that suggests that hyperphagia leading to obesity is associated with substantial neurochemical changes in the brain. These findings verify the relevance of reward pathways for promoting consumption of palatable, calorically dense foods, and lead to the important question of whether changes in reward circuitry in response to intake of such foods serve a causal role in the development and maintenance of some cases of obesity. Finally, we discuss the potential value for future studies at the intersection of the obesity epidemic and the neuroscience of motivation, as well as the potential concerns that arise from viewing excessive food intake as an "addiction". We suggest that it might be more useful to focus on overeating that results in frank obesity, and multiple health, interpersonal, and occupational negative consequences as a form of food "abuse".
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.