ArticleGenetic testing and molecular biomarkers2013
Gender, body mass index, and PPARγ polymorphism are good indicators in hyperuricemia prediction for Han Chinese.
Article in Genetic testing and molecular biomarkers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Influence of Gut Microbiota-Derived Butyrate on Intestinal Uric Acid Excretion and Hyperuricemia Regulation byInternational journal of molecular sciences · 2025Article
- Development and Validation of a Nomogram for Predicting Hyperuricemia in Perimenopausal Women.International journal of general medicine · 2025Article
- Hyperuricemia Remission After Sleeve Gastrectomy in Chinese Patients and Establishment of a Preoperative Predictive Model: A Retrospective Cohort Study with a Mean Follow-Up of 20 Months.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- One-Year Risk Prediction of Elevated Serum Uric Acid Levels in Older Adults: A Longitudinal Cohort Study.Clinical interventions in aging · 2024Article
- Article
- The elevated visceral adiposity index increases the risk of hyperuricemia in Chinese hypertensive patients: A cross-sectional study.Frontiers in endocrinology · 2022Article
- Associaton of Retinol Binding Protein 4 (RBP4) Levels With Hyperuricemia: A Cross-Sectional Study in a Chinese Population.Frontiers in endocrinology · 2022Article
- Early-life exposure to the Chinese famine of 1959-61 and risk of Hyperuricemia: results from the China health and retirement longitudinal study.BMC public health · 2020Article
- Sirt1 inhibits gouty arthritis via activating PPARγ.Clinical rheumatology · 2019Article
- Uric acid level changes after bariatric surgery in obese subjects with type 2 diabetes mellitus.Annals of translational medicine · 2019Article
- Using Blood Indexes to Predict Overweight Statuses: An Extreme Learning Machine-Based Approach.PloS one · 2015Article
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Authors and funding
8 authors at 7 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Hyperuricemia is closely associated with obesity and metabolic abnormalities, which is also an independent risk factor for cardiovascular diseases. The PPARγ gene, which is linked to obesity and metabolic abnormalities in Han Chinese, might be considered a top candidate gene that is involved in hyperuricemia. This study recruited 457 participants, aged 20-40 years old, to investigate the associations of the PPARγ gene and metabolic parameters with hyperuricemia. Three tag-single nucleotide polymorphisms, rs2292101, rs4684846, and rs1822825, of the PPARγ gene were selected to explore their association with hyperuricemia. Risk genotypes on rs1822825 of the PPARγ gene exhibited statistical significance with hyperuricemia (odds ratio: 1.9; 95% confidence interval: 1.05-3.57). Although gender, body mass index (BMI), serum total cholesterol concentration, or protein intake per day were statistically associated with hyperuricemia, the combination of BMI, gender, and rs1822825, rather than that of age, serum lipid profile, blood pressure, and protein intake per day, satisfied the predictability for hyperuricemia (sensitivity: 69.3%; specificity: 83.7%) in Taiwan-born obese Han Chinese. BMI, gender, and the rs1822825 polymorphism in the PPARγ gene appeared good biomarkers in hyperuricemia; therefore, these powerful indicators may be included in the prediction of hyperuricemia to increase the accuracy of the analysis.
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