Evidence map›Paper›PMID 23237606›Full record

ReviewMalaria journal2012

Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common.

Nicholas J White, Li Guo Qiao, Gao Qi, Lucio Luzzatto

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Malaria journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01872702 (Targeted Chemo-elimination), which is not on this map. Cited by 91 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 8 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01872702 nacompletednot on this mapstarted 2013, after this paper: background citation

Targeted Chemo-elimination (TCE) to Eradicate Malaria in Areas of Suspected or Proven Artemisinin Resistance in Southeast Asia and South Asia

TypeinterventionalSponsorUniversity of OxfordRan2013 to 2017Enrolled8,000ConditionsPlasmodium Falciparum MalariaArmsmalaria elimination using DP and low-dose primaquine
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 8 syntheses or guidelines pooled it, 153 citations in OpenAlex.

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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Nicholas J WhiteMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. nickw@tropmedres.ac
Li Guo Qiao
Gao Qi
Lucio Luzzatto
Guangzhou University of Chinese Medicine · CNJiangsu Institute of Parasitic Diseases · CNMahidol Oxford Tropical Medicine Research Unit · THTumour Institute of Tuscany · IT

Funding

Wellcome Trust 089275Wellcome Trust 093956
6 · The paper itself

Abstract

In areas of low malaria transmission, it is currently recommended that a single dose of primaquine (0.75 mg base/kg; 45 mg adult dose) be added to artemisinin combination treatment (ACT) in acute falciparum malaria to block malaria transmission. Review of studies of transmission-blocking activity based on the infectivity of patients or volunteers to anopheline mosquitoes, and of haemolytic toxicity in glucose 6-dehydrogenase (G6PD) deficient subjects, suggests that a lower primaquine dose (0.25 mg base/kg) would be safer and equally effective. This lower dose could be deployed together with ACTs without G6PD testing wherever use of a specific gametocytocide is indicated.

Indexed as

AdultAnemia, HemolyticAnimalsAnophelesAntimalarialsArtemisininsDrug Therapy, CombinationFemaleGlucosephosphate DehydrogenaseGlucosephosphate Dehydrogenase DeficiencyHumansInsect VectorsMalaria, FalciparumMaleParasitemiaPlasmodium falciparumAntimalarialsartemisininArtemisininsGlucosephosphate DehydrogenasePrimaquine

Identifiers

PMID23237606
PMCPMC3546849
OpenAlexW2037912215

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.