SynthesisReproductive biology and endocrinology : RB&E2012
The optimal duration of progesterone supplementation in pregnant women after IVF/ICSI: a meta-analysis.
Synthesis in Reproductive biology and endocrinology : RB&E, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Luteal phase support for assisted reproduction cycles.The Cochrane database of systematic reviews · 2015Pooled it
- Timing luteal support in assisted reproductive technology: a systematic review.Fertility and sterility · 2015Pooled it
- Progesterone supplementation in natural cycles improves live birth rates after embryo transfer of frozen-thawed embryos-a randomized controlled trial.Human reproduction (Oxford, England) · 2022Trial
- A randomized, controlled trial comparing the efficacy and safety of aqueous subcutaneous progesterone with vaginal progesterone for luteal phase support of in vitro fertilization.Human reproduction (Oxford, England) · 2014Trial
- Luteal phase support in assisted reproductive technology.Nature reviews. Endocrinology · 2024Review
- Impact of GnRH antagonist pretreatment on oocyte yield after ovarian stimulation: A retrospective analysis.PloS one · 2024Article
- Role of Dydrogesterone for Luteal Phase Support in Assisted Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Serum progesterone concentration on pregnancy test day might predict ongoing pregnancy after controlled ovarian stimulation and fresh embryo transfer.Frontiers in endocrinology · 2023Article
- Individualized luteal phase support after fresh embryo transfer: unanswered questions, a review.Reproductive health · 2022Review
- Key to Life: Physiological Role and Clinical Implications of Progesterone.International journal of molecular sciences · 2021Review
- A 10-year follow-up on the practice of luteal phase support using worldwide web-based surveys.Reproductive biology and endocrinology : RB&E · 2021Article
- The inadequate corpus luteum.Reproduction & fertility · 2021Article
- When Can We Safely Stop Luteal Phase Support in Fresh IVF Cycles? A Literature Review.Frontiers in reproductive health · 2020Review
- Luteal Phase Support in IVF: Comparison Between Evidence-Based Medicine and Real-Life Practices.Frontiers in endocrinology · 2020Article
- Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women.American journal of physiology. Endocrinology and metabolism · 2019Article
- In vitro progesterone production by luteinized human mural granulosa cells is modulated by activation of AMPK and cause of infertility.Reproductive biology and endocrinology : RB&E · 2017Article
- Progesterone administration for luteal phase deficiency in human reproduction: an old or new issue?Journal of ovarian research · 2015Review
- Progesterone and the luteal phase: a requisite to reproduction.Obstetrics and gynecology clinics of North America · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledcan improve the rates of clinical pregnancy and live birth, but the optimal duration of treatment remains controversial. The objective of this meta-analysis was to investigate the effects of early progesterone cessation on pregnancy outcomes in women undergoing IVF/ICSI.
methodsWe searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), the Chinese biomedicine (CBM) literature database, and the Wanfang database. The final search was performed in July 2012. All available randomised trials that compared the effects of early progesterone cessation with progesterone continuation during early pregnancy after IVF/ICSI were included. The main outcome measures were live birth rate, miscarriage rate and ongoing pregnancy rate. Fixed or random-effects models were chosen to calculate the risk ratio (RR).
resultsSix eligible studies with a total of 1,201 randomised participants were included in the final analysis. No statistically significant differences were detected between patients who underwent early progesterone cessation and those who received progesterone continuation for luteal phase support in terms of live birth rate (RR: 0.95, 95% CI: 0.86-1.05), miscarriage rate (RR: 1.01, 95% CI: 0.74-1.38) or ongoing pregnancy rate (RR: 0.97, 95% CI: 0.90-1.05). These results did not change after a sensitivity analysis.
conclusionsThe currently available evidence suggests that progesterone supplementation beyond the first positive hCG test after IVF/ICSI might generally be unnecessary, although large-scale randomised controlled trials are needed to strengthen this conclusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.