ArticlePloS one2012
Identification of conserved and novel microRNAs in cashmere goat skin by deep sequencing.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 67 citations in OpenAlex.
- Hair Follicles as Micro-Organs: MicroRNA-Mediated Control of Growth, Cycling, and Fiber Traits.Biomolecules · 2026Review
- Article
- Screening of microRNA and mRNA related to secondary hair follicle morphogenesis and development and functional analysis in cashmere goats.Functional & integrative genomics · 2022Article
- Article
- Expression profile of long non-coding RNA in inner Mongolian cashmere goat with putative roles in hair follicles development.Frontiers in veterinary science · 2022Article
- Screening of cashmere fineness-related genes and their ceRNA network construction in cashmere goats.Scientific reports · 2021Article
- Expression Profiling and Functional Analysis of Circular RNAs in Inner Mongolian Cashmere Goat Hair Follicles.Frontiers in genetics · 2021Article
- Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Related Potentially to the Fineness of Cashmere Fiber.Frontiers in genetics · 2021Article
- Expression of miRNA-203 and its target gene in hair follicle cycle development of Cashmere goat.Cell cycle (Georgetown, Tex.) · 2021Article
- Expression Profiling and Functional Characterization of miR-26a and miR-130a in Regulating Zhongwei Goat Hair Development via the TGF-β/SMAD Pathway.International journal of molecular sciences · 2020Article
- Chi-miR-30b-5p inhibits dermal papilla cells proliferation by targeting CaMKIIδ gene in cashmere goat.BMC genomics · 2020Article
- The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits.BMC developmental biology · 2020Article
- Analysis of histological and microRNA profiles changes in rabbit skin development.Scientific reports · 2020Article
- Comprehensive analysis of circRNAs from cashmere goat skin by next generation RNA sequencing (RNA-seq).Scientific reports · 2020Article
- miR-149-5p Regulates Goat Hair Follicle Stem Cell Proliferation and Apoptosis by Targeting the CMTM3/AR Axis During Superior-Quality Brush Hair Formation.Frontiers in genetics · 2020Article
- Expression profiles of microRNAs in skeletal muscle of sheep by deep sequencing.Asian-Australasian journal of animal sciences · 2019Article
- Article
- Identification of microRNA-21 target genes associated with hair follicle development in sheep.PeerJ · 2019Article
- High-throughput sequencing of hair follicle development-related micrornas in cashmere goat at various fetal periods.Saudi journal of biological sciences · 2018Article
- The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are a class of small RNAs that play significant roles in regulating the expression of the post-transcriptional skin and hair follicle gene. In recent years, extensive studies on these microRNAs have been carried out in mammals such as mice, rats, pigs and cattle. By comparison, the number of microRNAs that have been identified in goats is relatively low; and in particular, the miRNAs associated with the processes of skin and hair follicle development remain largely unknown. In this study, areas of skin where the cashmere grows in anagen were sampled. A total of 10,943,292 reads were obtained using Solexa sequencing, a high-throughput sequencing technology. From 10,644,467 reads, we identified 3,381 distinct reads and after applying the classification statistics we obtained 316 miRNAs. Among them, using conservative identification, we found that 68 miRNAs (55 of these are confirmed to match known sheep and goat miRNAs in miRBase ) are conserved in goat and have been reported in NCBI; the remaining 248 miRNA were conserved in other species but have not been reported in goat. Furthermore, we identified 22 novel miRNAs. Both the known and novel miRNAs were confirmed by a second sequencing using the same method as was used in the first. This study confirmed the authenticity of 316 known miRNAs and the discovery of 22 novel miRNAs in goat. We found that the miRNAs that were co-expressed in goat and sheep were located in the same region of the respective chromosomes and may play an essential role in skin and follicle development. Identificaton of novel miRNAs resulted in significant enrichment of the repertoire of goat miRNAs.
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