ArticleInternational journal of medical sciences2012
The diagnostic value of D-dimer, procalcitonin and CRP in acute appendicitis.
Article in International journal of medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03119740 (Clinical Value of Postoperative C-reactive Protein in the Detection of Complications After Open and Laparoscopic Appendectomy), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Value of Postoperative C-reactive Protein in the Detection of Complications After Open and Laparoscopic Appendectomy
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Biomarkers of acute appendicitis: systematic review and cost-benefit trade-off analysis.Surgical endoscopy · 2017Pooled it
- The Practice Guidelines for Primary Care of Acute Abdomen 2015.Japanese journal of radiology · 2016Guideline
- The diagnostic value of interleukin-6, procalcitonin, and C-reactive protein in the severity of acute appendicitis in children.Pediatric surgery international · 2026Article
- The Diagnostic Value of D-Dimer Testing in the Differential Diagnosis of Acute Abdomen in the Emergency Department.Journal of clinical medicine · 2026Review
- Analysis of predictive factors and development of a nomogram for complicated acute appendicitis in adults.BMC surgery · 2026Article
- Pro-adrenomedullin: a novel diagnostic biomarker of acute appendicitis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Value of Early Kinetics of Procalcitonin with Point-of-Care Test to Predict Postoperative Abscess Following Non-Complicated Acute Appendicitis: A Pilot Study.Medicina (Kaunas, Lithuania) · 2025Article
- Predictive model for identification of gangrenous or perforated appendicitis in adults: a multicenter retrospective study.BMC gastroenterology · 2024Article
- Pylephlebitis combined with septic shock secondary to acute nonperforated appendicitis: a case report.The Journal of international medical research · 2024Article
- Management of Intra-Abdominal Infections: The Role of Procalcitonin.Antibiotics (Basel, Switzerland) · 2023Review
- Review
- Negative Appendicectomy Rates in Females of Childbearing Age: A Retrospective Analysis and Literature Review.Cureus · 2022Article
- Role of inflammatory and hematological markers in predicting the complicated and perforated acute appendicitis in pediatric population: A cohort study.Annals of medicine and surgery (2012) · 2022Article
- Preoperatively predicting the pathological types of acute appendicitis using machine learning based on peripheral blood biomarkers and clinical features: a retrospective study.Annals of translational medicine · 2021Article
- Safety and efficacy of autologous non-hematopoietic enriched stem cell nebulization in COVID-19 patients: a randomized clinical trial, Abu Dhabi 2020.Translational medicine communications · 2021Article
- Plasma d-Dimer Levels in Non-prosthetic Orthopaedic Implant Infection: Can it Aid Diagnosis?Indian journal of orthopaedics · 2020Article
- Procalcitonin as an excellent differential marker between uncomplicated and complicated acute appendicitis in adult patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- A study of C-reactive protein and D-dimer in patients of appendicitis.Journal of family medicine and primary care · 2020Article
- Diagnostic efficacy of serum procalcitonin, IL-6, IL-2, and D-dimer levels in an experimental acute appendicitis model.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Utility of CD64 on Neutrophils in Orthopedic Infection.Yonago acta medica · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe early diagnosis of acute abdomen is of great importance. To date, several inflammatory markers have been used for the diagnosis of acute abdominal conditions, including acute appendicitis. The aim of this study was to evaluate the diagnostic utility of D-dimer, Procalcitonin (PCT) and C-reactive protein (CRP) measurements in the acute appendicitis.
methodsThis prospective study was conducted between March 1(st), 2010 and July 1(st), 2011. In this period, seventy-eight patients were operated with the diagnosis of acute appendicitis, and D-dimer, PCT and CRP levels of the patients were measured. The patients were grouped as phlegmonous appendicitis (Group 1), gangrenous appendicitis (Group 2), perforated appendicitis (Group 3) and negative appendectomy (Group 4) according to the surgical findings and histopathological results.
resultsOf 78 patients, 54 (69.2 %) were male and 24 (30.8 %) were female, and the mean age was 25.4 ± 11.1 years (range, 18 to 69 years). 66 (84.6 %) patients had increased leukocyte count (white blood cell count). The PCT values were higher than the upper normal limit in 20 (25.6%) patients, followed by D-dimer in 22 (28.2 %) patients and CRP in 54 (69.2 %) patients. The diagnostic value of leukocyte count and CRP in acute appendicitis was higher than that of the other markers, whereas leukocyte count showed very low specificity. CRP values were higher in perforated appendicitis when compared with the phlegmonous appendicitis (p < 0.05). However, PCT and D-dimer showed lower diagnostic values (26% and 31%, respectively).
conclusionAn increase in CRP levels alone is not sufficient to make the diagnosis of acute appendicitis. However, CRP levels may differentiate between phlegmonous appendicitis and perforated appendicitis. Due to their low sensitivity and diagnostic value, PCT and D-dimer are not better markers than CRP for the diagnosis of acute appendicitis.
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