ArticleWorld journal of gastroenterology2012
Tumour seeding after percutaneous cryoablation for hepatocellular carcinoma.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Are liver contour and bone fusion comparable to fiducials for IGRT in liver SBRT?Technical innovations & patient support in radiation oncology · 2023Article
- Development and validation of a clinicopathological-based nomogram to predict seeding risk after percutaneous thermal ablation of primary liver carcinoma.Cancer medicine · 2020Article
- Percutaneous cryoablation of subcapsular hepatocellular carcinoma: a retrospective study of 57 cases.Diagnostic and interventional radiology (Ankara, Turkey) · 2020Article
- Utilizing confocal laser endomicroscopy for evaluating the adequacy of laparoscopic liver ablation.Lasers in surgery and medicine · 2016Article
- Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated cases.Frontiers of medicine · 2015Article
- Long-term outcomes of percutaneous cryoablation for patients with hepatocellular carcinoma within Milan criteria.PloS one · 2015Article
- Percutaneous Cryoablation for Liver Cancer.Journal of clinical and translational hepatology · 2014Review
- High intratumoral metastasis-associated in colon cancer-1 expression predicts poor outcomes of cryoablation therapy for advanced hepatocellular carcinoma.Journal of translational medicine · 2013Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the rate and risk factors for tumour seeding in a large cohort of patients.
methodsOver an 8-year period, 1436 hepatocellular carcinoma (HCC) patients with 2423 tumour nodules underwent 3015 image-guided percutaneous cryoablation sessions [1215 guided by ultrasonography and 221 by spiral computed tomography (CT)]. Follow-up CT or magnetic resonance imaging was performed every 3 mo. The detailed clinical data were recorded to analyse the risk factors for seeding.
resultsThe median follow-up time was 18 (range 1-90) mo. Seeding was detected in 11 patients (0.76%) at 1-24 (median 6.0) mo after cryoablation. Seeding occurred along the needle tract in 10 patients and at a distant location in 1 patient. Seeded tumours usually showed similar imaging and histopathological features to the primary HCCs. Univariate analyses identified subcapsular tumour location and direct subcapsular needle insertion as risk factors for seeding. Multivariate analysis showed that only direct subcapsular needle insertion was an independent risk factor for seeding (P = 0.017; odds ratio 2.57; 95%CI: 1.47-3.65). Seeding after cryoablation occurred earlier in patients with poorly differentiated HCC than those with well or moderately differentiated HCC [1.33 ± 0.577 mo vs 11.12 ± 6.896 mo; P = 0.042; 95%CI: (-19.115)-(-0.468)].
conclusionThe risk of seeding after cryoablation for HCC is small. Direct puncture of subcapsular tumours should be avoided to minimise seeding.
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