ArticleProceedings of the National Academy of Sciences of the United States of America2012
Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 128 citations in OpenAlex.
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- Advances in nanostructured drug delivery systems for cardiovascular therapeutics.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2025Review
- Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications.International journal of molecular sciences · 2024Review
- Model Systems to Study the Mechanism of Vascular Aging.International journal of molecular sciences · 2023Review
- Photomodulated Extrusion as a Localized Endovascular Hydrogel Deposition Method.Advanced healthcare materials · 2023Article
- Conductive and Adhesive Granular Alginate Hydrogels for On-Tissue Writable Bioelectronics.Gels (Basel, Switzerland) · 2023Article
- Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives facilitate scarless wound healing.Bioactive materials · 2023Article
- Alginate: Enhancement Strategies for Advanced Applications.International journal of molecular sciences · 2022Review
- Regulatory perspectives of combination products.Bioactive materials · 2022Review
- Polydopamine nanoparticles and hyaluronic acid hydrogels for mussel-inspired tissue adhesive nanocomposites.Biomaterials advances · 2022Article
- Antibacterial Gel Coatings Inspired by the Cryptic Function of a Mussel Byssal Peptide.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Article
- Molecular design principles of Lysine-DOPA wet adhesion.Nature communications · 2020Article
- Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications.Chemical Society reviews · 2020Article
- Role of Dual-Specificity Phosphatase 1 in Glucocorticoid-Driven Anti-inflammatory Responses.Frontiers in immunology · 2019Review
- Recent Developments in Tough Hydrogels for Biomedical Applications.Gels (Basel, Switzerland) · 2018Review
- Cell Membrane Bioconjugation and Membrane-Derived Nanomaterials for Immunotherapy.Bioconjugate chemistry · 2018Review
- Nanoparticle-based local antimicrobial drug delivery.Advanced drug delivery reviews · 2018Review
- Mechanically Reinforced Catechol-Containing Hydrogels with Improved Tissue Gluing Performance.Biomimetics (Basel, Switzerland) · 2017Article
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Authors and funding
24 authors at 8 institutions in 3 countries.
Funding
Abstract
The treatment of diseased vasculature remains challenging, in part because of the difficulty in implanting drug-eluting devices without subjecting vessels to damaging mechanical forces. Implanting materials using adhesive forces could overcome this challenge, but materials have previously not been shown to durably adhere to intact endothelium under blood flow. Marine mussels secrete strong underwater adhesives that have been mimicked in synthetic systems. Here we develop a drug-eluting bioadhesive gel that can be locally and durably glued onto the inside surface of blood vessels. In a mouse model of atherosclerosis, inflamed plaques treated with steroid-eluting adhesive gels had reduced macrophage content and developed protective fibrous caps covering the plaque core. Treatment also lowered plasma cytokine levels and biomarkers of inflammation in the plaque. The drug-eluting devices developed here provide a general strategy for implanting therapeutics in the vasculature using adhesive forces and could potentially be used to stabilize rupture-prone plaques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.