ArticleProceedings of the National Academy of Sciences of the United States of America2012
Logic reversibility and thermodynamic irreversibility demonstrated by DNAzyme-based Toffoli and Fredkin logic gates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Quantum-inspired logic for advanced Transcriptional Programming.Nucleic acids research · 2025Article
- Construction and Application of DNAzyme-based Nanodevices.Chemical research in Chinese universities · 2023Review
- Catalyst-based biomolecular logic gates.Catalysts (Basel, Switzerland) · 2022Article
- A single layer artificial neural network type architecture with molecular engineered bacteria for reversible and irreversible computing.Chemical science · 2021Article
- Smart and Functionalized Development of Nucleic Acid-Based Hydrogels: Assembly Strategies, Recent Advances, and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- DNA-based constitutional dynamic networks as functional modules for logic gates and computing circuit operations.Chemical science · 2021Article
- Logic Gates Based on DNA Aptamers.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Computer-aided biochemical programming of synthetic microreactors as diagnostic devices.Molecular systems biology · 2018Article
- Consciousness as a Physical Process Caused by the Organization of Energy in the Brain.Frontiers in psychology · 2018Article
- Continuous variables logicChemical science · 2017Article
- High-resolution mapping of bifurcations in nonlinear biochemical circuits.Nature chemistry · 2016Article
- A survey of advancements in nucleic acid-based logic gates and computing for applications in biotechnology and biomedicine.Chemical communications (Cambridge, England) · 2015Article
- Reversible energy-transfer switching on a DNA scaffold.Journal of the American Chemical Society · 2015Article
- Ternary DNA computing using 3 × 3 multiplication matrices.Chemical science · 2015Article
- A Novel Computational Method to Reduce Leaky Reaction in DNA Strand Displacement.Journal of analytical methods in chemistry · 2015Article
- A biocatalytic cascade with several output signals--towards biosensors with different levels of confidence.Analytical and bioanalytical chemistry · 2014Article
- Molecular decision trees realized by ultrafast electronic spectroscopy.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Scaling down DNA circuits with competitive neural networks.Journal of the Royal Society, Interface · 2013Article
- An all-photonic molecule-based parity generator/checker for error detection in data transmission.Journal of the American Chemical Society · 2013Article
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4 authors.
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Abstract
The Toffoli and Fredkin gates were suggested as a means to exhibit logic reversibility and thereby reduce energy dissipation associated with logic operations in dense computing circuits. We present a construction of the logically reversible Toffoli and Fredkin gates by implementing a library of predesigned Mg(2+)-dependent DNAzymes and their respective substrates. Although the logical reversibility, for which each set of inputs uniquely correlates to a set of outputs, is demonstrated, the systems manifest thermodynamic irreversibility originating from two quite distinct and nonrelated phenomena. (i) The physical readout of the gates is by fluorescence that depletes the population of the final state of the machine. This irreversible, heat-releasing process is needed for the generation of the output. (ii) The DNAzyme-powered logic gates are made to operate at a finite rate by invoking downhill energy-releasing processes. Even though the three bits of Toffoli's and Fredkin's logically reversible gates manifest thermodynamic irreversibility, we suggest that these gates could have important practical implication in future nanomedicine.
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