ArticleSchizophrenia bulletin2014
Evaluating genetic counseling for individuals with schizophrenia in the molecular age.
Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Efficacy of Genetic Counseling for Psychiatric Disorders: a Meta-Analysis.Journal of genetic counseling · 2017Pooled it
- Recovery From Anorexia Nervosa: A Concept Analysis.Journal of advanced nursing · 2026Review
- Protocol for a new family history of addiction density score to aid in the treatment of alcohol and substance use disorders.Drug and alcohol dependence reports · 2025Article
- Genetic counselling for psychiatric conditions: exploring current perceptions of family physicians and psychiatrists in Portugal.Journal of community genetics · 2025Article
- Influences of race and clinical variables on psychiatric genetic research participation: Results from a schizophrenia sample.PloS one · 2023Article
- Perceptions of causal attribution and attitudes to genetic testing among people with schizophrenia and their first-degree relatives.European journal of human genetics : EJHG · 2022Article
- The impact of psychiatric disorders on caregivers: An integrative predictive model of burden, stigma, and well-being.Perspectives in psychiatric care · 2022Article
- An ethical analysis of divergent clinical approaches to the application of genetic testing for autism and schizophrenia.Human genetics · 2022Article
- Assessing Stakeholder Perceptions of the Utility of Genetic Information for the Clinical Care of Mental Health Disorders: We Have a Will but Need to See the Way.Administration and policy in mental health · 2021Article
- Evidence-Based Genetic Counseling for Psychiatric Disorders: A Road Map.Cold Spring Harbor perspectives in medicine · 2020Review
- Four Actionable Bottlenecks and Potential Solutions to Translating Psychiatric Genetics Research: An Expert Review.Public health genomics · 2020Review
- International Society of Psychiatric Genetics Ethics Committee: Issues facing us.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Review
- Parkinson's Disease: Patients' Knowledge, Attitudes, and Interest in Genetic Counseling.Journal of genetic counseling · 2018Article
- Training to Provide Psychiatric Genetic Counseling: How Does It Impact Recent Graduates' and Current Students' Readiness to Provide Genetic Counseling for Individuals with Psychiatric Illness and Attitudes towards this Population?Journal of genetic counseling · 2018Article
- Receptiveness to participation in genetic research: A pilot study comparing views of people with depression, diabetes, or no illness.Journal of psychiatric research · 2017Article
- Neuropsychiatric aspects of 22q11.2 deletion syndrome: considerations in the prenatal setting.Prenatal diagnosis · 2017Article
- How do Physicians Decide to Refer Their Patients for Psychiatric Genetic Counseling? A Qualitative Study of Physicians' Practice.Journal of genetic counseling · 2016Article
- Obsessive-Compulsive Disorder: The Process of Parental Adaptation and Implications for Genetic Counseling.Journal of genetic counseling · 2016Article
- Disclosure of psychiatric manifestations of 22q11.2 deletion syndrome in medical genetics: A 12-year retrospective chart review.American journal of medical genetics. Part A · 2015Article
- Ethical issues associated with genetic counseling in the context of adolescent psychiatry.Applied & translational genomics · 2015Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundRecent advances in schizophrenia genetics are shedding new light on etiopathogenesis, but issues germane to translation of findings into clinical practice are relatively understudied. We assessed the need for, and efficacy of, a contemporary genetic counseling protocol for individuals with schizophrenia.
methodsAfter characterizing rare copy number variation in a cohort of adults with schizophrenia, we recruited subjects from the majority of individuals who had no clinically relevant structural genetic variant. We used a pre-post study design with longitudinal follow-up to assess both the profile of need and the impact of general genetic counseling on key knowledge-based and psychological factors.
resultsThirty-nine (60.0%) of 65 patients approached actively expressed an interest in the study. At baseline, participants (n = 25) tended to overestimate the risk of familial recurrence of schizophrenia, express considerable concern related to this perceived risk, endorse myths about schizophrenia etiology, and blame themselves for their illness. Postcounseling, there was a significant improvement in understanding of the empiric recurrence risk (P = .0090), accompanied by a decrease in associated concern (P = .0020). There were also significant gains in subjective (P = .0007) and objective (P = .0103) knowledge, and reductions in internalized stigma (P = .0111) and self-blame (P = .0401). Satisfaction with genetic counseling, including endorsement of the need for such counseling (86.4%), was high.
conclusionsThese results provide initial evidence of need for, and efficacy of, genetic counseling for individuals with schizophrenia. The findings may help facilitate development of a contemporary genetic counseling process that could optimize outcomes in the nascent field of evidence-based psychiatric genetic counseling.
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