ArticleJournal of virology2013
Sequencing, annotation, and characterization of the influenza ferret infectome.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- Characterising the Transcriptomic Response to Interferon and Infection in European Domestic Ferret Respiratory Tissues Using Long-Read RNA Sequencing.Immunology · 2026Article
- Ferrets as a Mammalian Model to Study Influenza Virus-Bacteria Interactions.The Journal of infectious diseases · 2024Article
- Differential transcriptome response following infection of porcine ileal enteroids with species A and C rotaviruses.Virology journal · 2023Article
- Host Transcriptome Analysis of Ferret Tissues Following Henipavirus Infection.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Ferret Models for Henipavirus Infection.Methods in molecular biology (Clifton, N.J.) · 2023Article
- After the virus has cleared-Can preclinical models be employed for Long COVID research?PLoS pathogens · 2022Review
- Ferret Interferon (IFN)-Inducible Transmembrane Proteins Are Upregulated by both IFN-α and Influenza Virus Infection.Journal of virology · 2021Article
- Review
- Immune Imprinting in the Influenza Ferret Model.Vaccines · 2020Review
- Purification of poly-dA oligonucleotides and mRNA-protein fusions with dTBioorganic & medicinal chemistry letters · 2020Article
- Article
- Improving immunological insights into the ferret model of human viral infectious disease.Influenza and other respiratory viruses · 2019Review
- Review
- Host gene expression profiles in ferrets infected with genetically distinct henipavirus strains.PLoS neglected tropical diseases · 2018Article
- Advanced nanotechnologies in avian influenza: Current status and future trends - A review.Analytica chimica acta · 2017Review
- Influenza-Omics and the Host Response: Recent Advances and Future Prospects.Pathogens (Basel, Switzerland) · 2017Review
- Article
- Generation of Monoclonal Antibodies against Immunoglobulin Proteins of the Domestic Ferret (Journal of immunology research · 2017Article
- Using the Ferret as an Animal Model for Investigating Influenza Antiviral Effectiveness.Frontiers in microbiology · 2016Review
- Characterization of the Localized Immune Response in the Respiratory Tract of Ferrets following Infection with Influenza A and B Viruses.Journal of virology · 2015Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ferrets have become an indispensable tool in the understanding of influenza virus virulence and pathogenesis. Furthermore, ferrets are the preferred preclinical model for influenza vaccine and therapeutic testing. Here we characterized the influenza infectome during the different stages of the infectious process in ferrets with and without prior specific immunity to influenza. RNA from lung tissue and lymph nodes from infected and naïve animals was subjected to next-generation sequencing, followed by de novo data assembly and annotation of the resulting sequences; this process generated a library comprising 13,202 ferret mRNAs. Gene expression profiles during pandemic H1N1 (pdmH1N1) influenza virus infection were analyzed by digital gene expression and solid support microarrays. As expected during primary infection, innate immune responses were triggered in the lung tissue; meanwhile, in the lymphoid tissue, genes encoding antigen presentation and maturation of effector cells of adaptive immunity increased dramatically. After 5 days postinfection, the innate immune gene expression was replaced by the adaptive immune response, which correlates with viral clearance. Reinfection with homologous pandemic influenza virus resulted in a diminished innate immune response, early adaptive immune gene regulation, and a reduction in clinical severity. The fully annotated ferret infectome will be a critical aid to the understanding of the molecular events that regulate disease severity and host-influenza virus interactions among seasonal, pandemic, and highly pathogenic avian influenzas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.