ArticleJournal of neurophysiology2013
Neural control of muscle force: indications from a simulation model.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Thigh musculature stiffness during active muscle contraction after anterior cruciate ligament injury.BMC musculoskeletal disorders · 2020Trial
- Differential motor unit firing rate and hypertrophic adaptations of the vastus lateralis despite similar strength increases following high-load versus combined high- and low-load resistance training interventions.Experimental brain research · 2026Article
- Effect of hypoxia on muscle activation at equivalent absolute and relative intensity during incremental and constant load exercise to task failure.Experimental physiology · 2026Article
- Matching dynamically varying forces with multi-motor-unit muscle models: a simulation study.Royal Society open science · 2025Article
- Can non-invasive motor unit analysis reveal distinct neural strategies of force production in young with uncomplicated type 1 diabetes?European journal of applied physiology · 2025Article
- Blood flow restriction increases necessary muscle excitation of the elbow flexors during a single high-load contraction.European journal of applied physiology · 2024Article
- Article
- Motor unit-based synergies in a non-compartmentalized muscle.Experimental brain research · 2023Article
- Ankle Torque Estimation With Motor Unit Discharges in Residual Muscles Following Lower-Limb Amputation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- Resistance exercise training and the motor unit.European journal of applied physiology · 2022Review
- The influence of chronic training status on the mechanical behavior of the vastus lateralis during repetitive trapezoidal contractions.Journal of musculoskeletal & neuronal interactions · 2022Article
- How to Work with Electromyography Decomposition in Practical Classes of Exercise Physiology and Biomechanics.Life (Basel, Switzerland) · 2022Article
- Method of analysis influences interpretations of sex-related differences in firing rates during prolonged submaximal isometric contractions.Journal of musculoskeletal & neuronal interactions · 2022Article
- Effects of continuous cycling training on motor unit firing rates, input excitation, and myosin heavy chain of the vastus lateralis in sedentary females.Experimental brain research · 2022Article
- EMG-driven musculoskeletal model calibration with estimation of unmeasured muscle excitationsFrontiers in bioengineering and biotechnology · 2022Article
- Synergies at the level of motor units in single-finger and multi-finger tasks.Experimental brain research · 2021Article
- On the reliability and validity of central fatigue determination.European journal of applied physiology · 2021Review
- Motor unit action potential amplitude during low torque fatiguing contractions versus high torque non-fatiguing contractions: a multilevel analysis.European journal of applied physiology · 2021Article
- Sex-related differences in motor unit firing rates and action potential amplitudes of the first dorsal interosseous during high-, but not low-intensity contractions.Experimental brain research · 2020Article
- Evaluation of Synergy Extrapolation for Predicting Unmeasured Muscle Excitations from Measured Muscle Synergies.Frontiers in computational neuroscience · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We developed a model to investigate the influence of the muscle force twitch on the simulated firing behavior of motoneurons and muscle force production during voluntary isometric contractions. The input consists of an excitatory signal common to all the motor units in the pool of a muscle, consistent with the "common drive" property. Motor units respond with a hierarchically structured firing behavior wherein at any time and force, firing rates are inversely proportional to recruitment threshold, as described by the "onion skin" property. Time- and force-dependent changes in muscle force production are introduced by varying the motor unit force twitches as a function of time or by varying the number of active motor units. A force feedback adjusts the input excitation, maintaining the simulated force at a target level. The simulations replicate motor unit behavior characteristics similar to those reported in previous empirical studies of sustained contractions: 1) the initial decrease and subsequent increase of firing rates, 2) the derecruitment and recruitment of motor units throughout sustained contractions, and 3) the continual increase in the force fluctuation caused by the progressive recruitment of larger motor units. The model cautions the use of motor unit behavior at recruitment and derecruitment without consideration of changes in the muscle force generation capacity. It describes an alternative mechanism for the reserve capacity of motor units to generate extraordinary force. It supports the hypothesis that the control of motoneurons remains invariant during force-varying and sustained isometric contractions.
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