ArticleNature2012
A soybean cyst nematode resistance gene points to a new mechanism of plant resistance to pathogens.
Article in Nature, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 199 papers.
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Who cites it
199 citing papers in PubMed, 401 citations in OpenAlex.
- Oligomeric defects in soybean serine hydroxymethyltransferase 8: tetramer destabilization by A149T and other variants associated with soybean cyst nematode resistance.The FEBS journal · 2026Article
- Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Time- and Genotype-Dependent Root-Transcriptomic Responses of Soybean to Combined Soybean Aphid and Soybean Cyst Nematode Infestation.Plants (Basel, Switzerland) · 2026Article
- Genome-wide association study of soybean germplasm derived from modern Canadian and Chinese soybean cultivars to identify novel genes conferring soybean cyst nematode resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- A Rapid and Visual Soybean Hairy Root Transformation Protocol Using the RUBY Reporter.Bio-protocol · 2026Article
- The current state of Japanese soybean breeding using DNA marker technology.Breeding science · 2026Article
- Molecular polymorphisms that underlie trait variation in crops: Lessons learned from soybean.The plant genome · 2026Review
- Pangenome analysis of nine soybean cyst nematode genomes reveals hidden variation contributing to diversity and adaptation.BMC genomics · 2026Article
- Functional divergence of two soybean cytosolic serine hydroxymethyltransferases in development and defense against soybean cyst nematode.Frontiers in plant science · 2026Article
- Applications of the Soybean Expression Atlas in Genomics and Transcriptomics Research.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Light-Signalling Regulators GmSTF3/4 Enhance Soybean Susceptibility to Cyst Nematodes via Activation of Sugar Transporters.Plant biotechnology journal · 2025Article
- Transcription FactorPlants (Basel, Switzerland) · 2025Article
- Candidate genes at the Rmi1 locus for resistance to Meloidogyne incognita in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Identification of candidate genes associated with resistance to Heterodera sojae in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Transcriptome analysis reveals key pathways and regulatory networks involved in soybean's early resistance to Peronospora manshurica.BMC plant biology · 2025Article
- A telomere-to-telomere genome of wild soybean with resistance to soybean cyst nematode X12.Scientific data · 2025Article
- Integrated transcriptome and BSA-seq analysis identifies a novel QTL for Meloidogyne graminicola resistance in rice HuaHang31.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- The AP2/ERF transcription factor GmTINY mediates ethylene regulation of Rhg1-conferred resistance against soybean cyst nematode.Plant communications · 2025Article
- Gene Localization and Functional Validation ofPlants (Basel, Switzerland) · 2025Article
- Overexpression of the GmERF071 gene confers resistance to soybean cyst nematode in soybean.The plant genome · 2025Article
139 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soybean (Glycine max (L.) Merr.) is an important crop that provides a sustainable source of protein and oil worldwide. Soybean cyst nematode (Heterodera glycines Ichinohe) is a microscopic roundworm that feeds on the roots of soybean and is a major constraint to soybean production. This nematode causes more than US$1 billion in yield losses annually in the United States alone, making it the most economically important pathogen on soybean. Although planting of resistant cultivars forms the core management strategy for this pathogen, nothing is known about the nature of resistance. Moreover, the increase in virulent populations of this parasite on most known resistance sources necessitates the development of novel approaches for control. Here we report the map-based cloning of a gene at the Rhg4 (for resistance to Heterodera glycines 4) locus, a major quantitative trait locus contributing to resistance to this pathogen. Mutation analysis, gene silencing and transgenic complementation confirm that the gene confers resistance. The gene encodes a serine hydroxymethyltransferase, an enzyme that is ubiquitous in nature and structurally conserved across kingdoms. The enzyme is responsible for interconversion of serine and glycine and is essential for cellular one-carbon metabolism. Alleles of Rhg4 conferring resistance or susceptibility differ by two genetic polymorphisms that alter a key regulatory property of the enzyme. Our discovery reveals an unprecedented plant resistance mechanism against a pathogen. The mechanistic knowledge of the resistance gene can be readily exploited to improve nematode resistance of soybean, an increasingly important global crop.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.