SynthesisThe Cochrane database of systematic reviews2012
Oral betamimetics for maintenance therapy after threatened preterm labour.
Synthesis in The Cochrane database of systematic reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Home uterine monitoring for detecting preterm labour.The Cochrane database of systematic reviews · 2017Pooled it
- Betamimetics for inhibiting preterm labour.The Cochrane database of systematic reviews · 2014Pooled it
- Transdermal nitroglycerin for the treatment of preterm labor: a systematic review and metaanalysis.American journal of obstetrics and gynecology · 2013Pooled it
- Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour.The Cochrane database of systematic reviews · 2013Pooled it
- Maintenance therapy with oxytocin antagonists for inhibiting preterm birth after threatened preterm labour.The Cochrane database of systematic reviews · 2013Pooled it
- Vaginal Progesterone for Pregnancy Prolongation After Arrested Preterm Labor: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Prolonged administration of ritodrine hydrochloride in women with premature labor or threatened premature delivery based on empirical data in Japan.Scientific reports · 2025Article
- Efficacy of Transdermal Nitroglycerin Patch for the Arrest of Preterm Labor: A Retrospective Study.Cureus · 2024Article
- Prevalence and changes of low-value care at acute care hospitals: a multicentre observational study in Japan.BMJ open · 2022Observational
- Interventions for the prevention of spontaneous preterm birth: a scoping review of systematic reviews.BMJ open · 2022Article
- Landscape of Preterm Birth Therapeutics and a Path Forward.Journal of clinical medicine · 2021Review
- Prevention and Therapy of Preterm Birth. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015/025, February 2019) - Part 2 with Recommendations on the Tertiary Prevention of Preterm Birth and the Management of Preterm Premature Rupture of Membranes.Geburtshilfe und Frauenheilkunde · 2019Article
- Incidence and risk factors of neonatal hypoglycemia after ritodrine therapy in premature labor: a retrospective cohort study.Journal of pharmaceutical health care and sciences · 2019Article
- Acute Tocolysis - a Critical Analysis of Evidence-Based Data.Geburtshilfe und Frauenheilkunde · 2018Article
- A novel molecular microbiologic technique for the rapid diagnosis of microbial invasion of the amniotic cavity and intra-amniotic infection in preterm labor with intact membranes.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Article
Corrections and comments
- Update of
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome women who have threatened to give birth prematurely, subsequently settle. They may then take oral tocolytic maintenance therapy to prevent preterm birth and to prolong gestation.
objectivesTo assess the effects of oral betamimetic maintenance therapy after threatened preterm labour for preventing preterm birth. SEARCH
methodsWe updated the search of the Cochrane Pregnancy and Childbirth Group's Trials Register on 9 November 2012. SELECTION CRITERIA: Randomised controlled trials comparing oral betamimetic with alternative tocolytic therapy, placebo or no therapy, for maintenance following treatment of threatened preterm labour. DATA COLLECTION AND ANALYSIS: Two review authors independently applied the selection criteria and carried out data extraction and quality assessment of studies. MAIN
resultsWe did not identify any new trials from the updated search so the results remain unchanged as follows.We included 13 randomised controlled trials (RCTs) with a total of 1551 women. We found no differences for admission to the neonatal intensive care unit when betamimetics were compared with placebo (risk ratio (RR) 1.28, 95% confidence interval (CI) 0.68 to 2.41; two RCTs of terbutaline with 2600 women) or with magnesium (RR 0.80, 95% CI 0.43 to 1.46; one RCT of 137 women). The rate of preterm birth (less than 37 weeks) showed no significant difference in six RCTs, four comparing ritodrine with placebo/no treatment and two comparing terbutaline with placebo/no treatment (RR 1.11, 95% CI 0.91 to 1.35; 644 women). We observed no differences between betamimetics and placebo, no treatment or other tocolytics for perinatal mortality and morbidity outcomes. Some adverse effects such as tachycardia were more frequent in the betamimetics groups than the groups allocated to placebo, no treatment or another type of tocolytic. AUTHORS'
conclusionsAvailable evidence does not support the use of oral betamimetics for maintenance therapy after threatened preterm labour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.