ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2013
Correlation of computed tomography with histopathology in otosclerosis.
Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Diagnostic yield of MRI for pediatric hearing loss: a systematic review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2015Pooled it
- Symons and Fanning Classification in Otosclerosis and Its Relation to Audiologic Parameters, Stapes Footplate Thickness, and Round Window Involvement.Audiology & neuro-otology · 2026Article
- Labyrinthine Abnormalities on MRI in Untreated Otosclerosis: Prevalence and Clinical Relevance.The Laryngoscope · 2026Observational
- Conductive hearing loss and normal CT: a clinical perspective.Neuroradiology · 2026Review
- Population-based differences in otosclerosis: a dual-center study of radiological and audiological comparison in Chinese and Swiss patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Imaging features of otosclerosis on photon counting detector CT: a retrospective case series and literature review.Neuroradiology · 2026Observational
- Current trends in imaging for otosclerosis and the potential role of photon-counting computed tomography.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025Review
- A White Spot Around the Fissula Ante Fenestrum: A New Diagnostic Indicator for Otosclerosis.Journal of clinical medicine · 2025Article
- Histopathological Patterns of Otosclerosis Progression: Exploring Otic Capsule and Round Window Involvement.The Laryngoscope · 2025Article
- A comparison between endoscopic and microscopic approaches for stapes surgery: experience of a tertiary referral center.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Patterns of Signal Intensity in CISS MRI of the Inner Ear and Eye.Tomography (Ann Arbor, Mich.) · 2024Article
- Vertigo Associated with Otosclerosis and Stapes Surgery-A Narrative Review.Medicina (Kaunas, Lithuania) · 2023Review
- Missed Radiological Diagnosis of Otosclerosis in High-Resolution Computed Tomography of the Temporal Bone-Retrospective Analysis of Imaging, Radiological Reports, and Request Forms.Journal of clinical medicine · 2023Article
- The use of explainable artificial intelligence to explore types of fenestral otosclerosis misdiagnosed when using temporal bone high-resolution computed tomography.Annals of translational medicine · 2021Article
- The Diagnostic Yield of Cone-Beam Computed Tomography for Degenerative Changes of the Temporomandibular Joint in Dogs.Frontiers in veterinary science · 2021Article
- Current Trends, Controversies, and Future Directions in the Evaluation and Management of Superior Canal Dehiscence Syndrome.Frontiers in neurology · 2021Review
- Otosclerosis: anatomical distribution of otosclerotic loci analyzed by high-resolution computed tomography.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Article
- Cavitary Plaques in Otospongiosis: CT Findings and Clinical Implications.AJNR. American journal of neuroradiology · 2018Article
- Lack of Evidence for Nonotosclerotic Stapes Fixation in Human Temporal Bone Histopathology.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2016Article
- Temporal Bone Histopathology in NOG-Symphalangism Spectrum Disorder.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2015Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveUntil now, the use of computed tomography (CT) in the diagnosis and evaluation of otosclerosis has been based on correlation of radiologic findings to patient histories, intraoperative examinations, and audiologic data. The purpose of this study was to compare CT findings in otosclerosis to histopathology. STUDY
designProspective blinded.
settingRadiology department in a tertiary referral hospital and otopathology laboratory. PATIENTS: Temporal bones from patients with otosclerosis and other otologic diseases (used as controls). INTERVENTION(S): Blinded review of specimen CT scans by radiologists and comparison of CT findings to histopathology of the same bones. MAIN OUTCOME MEASURE(S): Ability of CT to diagnose otosclerosis, identify otosclerotic foci in defined zones of the otic capsule, determine endosteal layer involvement, oval window (OW) obliteration, and round window (RW) obliteration.
resultsIn a randomized blinded evaluation, radiologists identified 8 of 10 bones with otosclerosis and made 3 false-positive diagnoses from the 36 control bones. Radiologic examination correctly identified otosclerosis anterior to the oval window, in the pericochlear area, and in the round window niche in 17 of 17, 9 of 11, and 3 of 6 bones, respectively. CT correctly determined involvement of the endosteal layer, OW obliteration, and RW obliteration in 5 of 8, 2 of 2, and 2 of 2 temporal bones.
conclusionHigh-resolution CT is highly sensitive and specific for the diagnosis of otosclerosis when compared with histopathology. Very small and subtle otosclerotic foci seen on pathology may be missed on CT. Although CT was able to positively identify cochlear endosteal margin involvement, the false-negative rate on CT was significant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.