ArticleViruses2012
Identification and characterization of a novel alpaca respiratory coronavirus most closely related to the human coronavirus 229E.
Article in Viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 75 citations in OpenAlex.
- Alpha- and Beta-Coronaviruses in Humans and Animals: Taxonomy, Reservoirs, Hosts, and Interspecies Transmission.Microorganisms · 2025Review
- Distribution of aminopeptidase N coronavirus receptors in the respiratory and digestive tracts of domestic and wild artiodactyls and carnivores.The Journal of general virology · 2025Article
- The reverse zoonotic potential of SARS-CoV-2.Heliyon · 2024Review
- Co-Circulation of Multiple Coronavirus Genera and Subgenera during an Epizootic of Lethal Respiratory Disease in Newborn Alpacas (Animals : an open access journal from MDPI · 2023Article
- SARS-CoV-2 prevalence in domestic and wildlife animals: A genomic and docking based structural comprehensive review.Heliyon · 2023Review
- Spike-Independent Infection of Human Coronavirus 229E in Bat Cells.Microbiology spectrum · 2023Article
- Evaluating the Virology and Evolution of Seasonal Human Coronaviruses Associated with the Common Cold in the COVID-19 Era.Microorganisms · 2023Review
- Extensive Recombination-driven Coronavirus Diversification Expands the Pool of Potential Pandemic Pathogens.Genome biology and evolution · 2022Article
- Human coronaviruses: Origin, host and receptor.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2022Review
- Why do some coronaviruses become pandemic threats when others do not?PLoS biology · 2022Article
- Virome characterization of game animals in China reveals a spectrum of emerging pathogens.Cell · 2022Article
- Structural Requirements and Plasticity of Receptor-Binding Domain in Human Coronavirus Spike.Frontiers in molecular biosciences · 2022Review
- Evolutionary Dynamics and Epidemiology of Endemic and Emerging Coronaviruses in Humans, Domestic Animals, and Wildlife.Viruses · 2021Review
- Evolutionary trajectory of SARS-CoV-2 and emerging variants.Virology journal · 2021Review
- Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens.bioRxiv : the preprint server for biology · 2021Article
- Molecular diversity of coronavirus host cell entry receptors.FEMS microbiology reviews · 2021Review
- Clinical and molecular aspects of veterinary coronaviruses.Virus research · 2021Review
- Coronavirus surveillance in wildlife from two Congo basin countries detects RNA of multiple species circulating in bats and rodents.PloS one · 2021Article
- The taxonomy, host range and pathogenicity of coronaviruses and other viruses in theAnimal diseases · 2021Review
- Coronavirus Infections of Animals: Future Risks to Humans.Biology bulletin of the Russian Academy of Sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2007, a novel coronavirus associated with an acute respiratory disease in alpacas (Alpaca Coronavirus, ACoV) was isolated. Full-length genomic sequencing of the ACoV demonstrated the genome to be consistent with other Alphacoronaviruses. A putative additional open-reading frame was identified between the nucleocapsid gene and 3'UTR. The ACoV was genetically most similar to the common human coronavirus (HCoV) 229E with 92.2% nucleotide identity over the entire genome. A comparison of spike gene sequences from ACoV and from HCoV-229E isolates recovered over a span of five decades showed the ACoV to be most similar to viruses isolated in the 1960's to early 1980's. The true origin of the ACoV is unknown, however a common ancestor between the ACoV and HCoV-229E appears to have existed prior to the 1960's, suggesting virus transmission, either as a zoonosis or anthroponosis, has occurred between alpacas and humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.