ArticleThe American journal of clinical nutrition2013
Altered hypothalamic response to food in smokers.
Article in The American journal of clinical nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Hunger and BMI modulate neural responses to sweet stimuli: fMRI meta-analysis.International journal of obesity (2005) · 2020Pooled it
- Elevated reward response to receipt of palatable food predicts future weight variability in healthy-weight adolescents.The American journal of clinical nutrition · 2017Trial
- Obesity is associated with greater variability of reward signals in the nucleus accumbens.Translational psychiatry · 2026Article
- Differential brain response to a highly palatable drink in chronic low back pain patients.Journal of neurophysiology · 2026Article
- GLP-1 receptor agonists for smoking cessation: a narrative review of weight management potential.Annals of medicine and surgery (2012) · 2026Article
- Salient cue reactivity and eating behaviors in ex-smokers, abstinent alcohol use disorder, and obesity.Frontiers in psychiatry · 2026Article
- The role of Neurochemicals, Stress Hormones and Immune System in the Positive Feedback Loops between Diabetes, Obesity and Depression.Frontiers in endocrinology · 2023Review
- The Effect of Smoking Cessation on Body Weight and Other Metabolic Parameters with Focus on People with Type 2 Diabetes Mellitus.International journal of environmental research and public health · 2022Review
- Dietary adaptation for weight loss maintenance at Yale (DAWLY): Protocol and predictions for a randomized controlled trial.Frontiers in nutrition · 2022Article
- Brain responses to anticipatory cues and milkshake taste in obesity, and their relationship to bariatric surgery outcome.NeuroImage · 2021Article
- Neural Vulnerability Factors That Predict Future Weight Gain.Current obesity reports · 2021Review
- What Do You Want to Eat? Influence of Menu Description and Design on Consumer's Mind: An fMRI Study.Foods (Basel, Switzerland) · 2021Article
- An Exploration of the Role of Sugar-Sweetened Beverage in Promoting Obesity and Health Disparities.Current obesity reports · 2021Review
- Much Ado About Missingness: A Demonstration of Full Information Maximum Likelihood Estimation to Address Missingness in Functional Magnetic Resonance Imaging Data.Frontiers in neuroscience · 2021Article
- The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective.Frontiers in nutrition · 2021Review
- Brain Responses to Food Odors Associated With BMI Change at 2-Year Follow-Up.Frontiers in human neuroscience · 2020Article
- Good practice in food-related neuroimaging.The American journal of clinical nutrition · 2019Article
- Neural vulnerability factors for obesity.Clinical psychology review · 2019Review
- Tobacco Smoking, Eating Behaviors, and Body Weight: A Review.Current addiction reports · 2019Article
- Early weight gain after stopping smoking: a predictor of overall large weight gain? A single-site retrospective cohort study.BMJ open · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSmoking cessation is often followed by weight gain. Eating behaviors and weight change have been linked to the brain response to food, but it is unknown whether smoking influences this response.
objectiveWe determined the influence of smoking status (smokers compared with nonsmokers) on the brain response to food in regions associated with weight changes in nonsmokers.
designIn study 1, we used functional MRI (fMRI) to identify regions of the brain associated with weight change in nonsmokers. BMI and the brain response to a milk shake, which is a palatable and energy-dense food, were measured in a group of 27 nonsmokers (5 men). Sixteen subjects (3 men) returned 1 y later for BMI reassessment. The change in BMI was regressed against the brain response to isolate regions associated with weight change. In study 2, to determine whether smokers showed altered responses in regions associated with weight change, we assessed the brain response to a milk shake in 11 smokers. The brain response to a milk shake compared with a tasteless control solution was assessed in 11 smokers (5 men) in comparison with a group of age-, sex- and body weight-matched nonsmokers selected from the pool of nonsmokers who participated in study 1.
resultsThe response in the midbrain, hypothalamus, thalamus, and ventral striatum was positively associated with weight change at the 1-y follow-up in 16 nonsmokers. Compared with nonsmokers, smokers had a greater response to milk shakes in the hypothalamus.
conclusionSmokers display an altered brain response to food in the hypothalamus, which is an area associated with long-term weight change in nonsmokers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.