ArticleExperimental gerontology2013
Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae.
Article in Experimental gerontology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Anhydrobiosis as a Model of Aging and Longevity: The Role of Autophagy and Metabolism in Yeast Cells.Microbial ecology · 2026Review
- Article
- Disturbances in cell wall biogenesis as a key factor in the replicative aging of budding yeast.Biogerontology · 2025Article
- The core genetic drivers of chronological aging in yeast are universal regulators of longevity.Microbial cell (Graz, Austria) · 2025Article
- Article
- Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites, and pathways that regulate lifespan.GeroScience · 2023Article
- The Effect of Calorie Restriction on Protein Quality Control in Yeast.Biomolecules · 2023Review
- Increasing the number of ribosomal uL6 mRNA copies accelerates aging of the budding yeast.Molecular biology reports · 2023Article
- Article
- The Effect of Lithium on the Budding YeastMicroorganisms · 2022Article
- Yeast YPK9 deficiency results in shortened replicative lifespan and sensitivity to hydrogen peroxide.Biogerontology · 2021Article
- Seeking Insights into Aging Through Yeast Mitochondrial Electrophysiology.Bioelectricity · 2021Article
- Replicative Aging in Pathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2020Review
- Reproductive Potential of Yeast Cells Depends on Overall Action of Interconnected Changes in Central Carbon Metabolism, Cellular Biosynthetic Capacity, and Proteostasis.International journal of molecular sciences · 2020Article
- Trajectories of Aging: How Systems Biology in Yeast Can Illuminate Mechanisms of Personalized Aging.Proteomics · 2020Review
- Diverse conditions support near-zero growth in yeast: Implications for the study of cell lifespan.Microbial cell (Graz, Austria) · 2019Review
- Review
- Some Metabolites Act as Second Messengers in Yeast Chronological Aging.International journal of molecular sciences · 2018Review
- pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity.Microbial cell (Graz, Austria) · 2018Review
- Ras signaling in aging and metabolic regulation.Nutrition and healthy aging · 2017Review
Corrections and comments
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Authors and funding
36 authors.
Funding
Abstract
Chronological aging of budding yeast cells results in a reduction in subsequent replicative life span through unknown mechanisms. Here we show that dietary restriction during chronological aging delays the reduction in subsequent replicative life span up to at least 23days of chronological age. We further show that among the viable portion of the control population aged 26days, individual cells with the lowest mitochondrial membrane potential have the longest subsequent replicative lifespan. These observations demonstrate that dietary restriction modulates a common molecular mechanism linking chronological and replicative aging in yeast and indicate a critical role for mitochondrial function in this process.
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Registered trials
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