ArticleThe American naturalist2013
Pathogen diversity and hidden regimes of apparent competition.
Article in The American naturalist, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Seven-valent pneumococcal conjugate vaccine and nasopharyngeal microbiota in healthy children.Emerging infectious diseases · 2014Trial
- Pathogen diversity in meta-population networks.Chaos, solitons, and fractals · 2023Article
- Landscape Seroprevalence of Three Hemorrhagic Disease-Causing Viruses in a Wild Cervid.EcoHealth · 2021Article
- Predicting N-Strain Coexistence from Co-colonization Interactions: Epidemiology Meets Ecology and the Replicator Equation.Bulletin of mathematical biology · 2020Article
- Frequency-dependent selection can forecast evolution in Streptococcus pneumoniae.PLoS biology · 2020Article
- Epidemiological consequences of enduring strain-specific immunity requiring repeated episodes of infection.PLoS computational biology · 2020Article
- Interplay between competitive and cooperative interactions in a three-player pathogen system.Royal Society open science · 2020Article
- Leaf Endophytes ofFrontiers in microbiology · 2020Article
- Linking community assembly and structure across scales in a wild mouse parasite community.Ecology and evolution · 2019Article
- Infection sequence alters disease severity-Effects of the sequential exposure of two larval trematodes toEcology and evolution · 2019Article
- A host immune hormone modifies parasite species interactions and epidemics: insights from a field manipulation.Proceedings. Biological sciences · 2018Article
- Vaccination can drive an increase in frequencies of antibiotic resistance among nonvaccine serotypes ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- An ecosystem framework for understanding and treating disease.Evolution, medicine, and public health · 2018Review
- A nutrient mediates intraspecific competition between rodent malaria parasitesProceedings. Biological sciences · 2017Article
- Host-Multi-Pathogen Warfare: Pathogen Interactions in Co-infected Plants.Frontiers in plant science · 2017Review
- Influence of Massive and Long Distance Migration on Parasite Epidemiology: Lessons from the Great Wildebeest Migration.EcoHealth · 2016Article
- Density, Serotype Diversity, and Fitness of Streptococcus pneumoniae in Upper Respiratory Tract Cocolonization With Nontypeable Haemophilus influenzae.The Journal of infectious diseases · 2016Article
- Clinical and Epidemiological Evidence of the Red Queen Hypothesis in Pneumococcal Serotype Dynamics.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- The role of hyperparasitism in microbial pathogen ecology and evolution.The ISME journal · 2016Review
- Modeling infectious disease dynamics in the complex landscape of global health.Science (New York, N.Y.) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Competition through cross-reacting host immune responses, a form of apparent competition, is a major driver of pathogen evolution and diversity. Most models of pathogens have focused on intraspecific interactions to explain observed patterns. Two recent experiments suggested that Haemophilus influenzae, a common nasopharyngeal colonizer of humans, might alter the immune environment in a way that favors otherwise less fit serotypes of another common pathogen, pneumococcus. Using a computational model, we demonstrate that H. influenzae, if it consistently raises the fitness of the less fit serotypes, can strongly promote pneumococcal diversity. However, the effects of H. influenzae are so sensitive to the prevalence of H. influenzae that this species is unlikely to be the main driver of serotype coexistence. Interactions that significantly affect diversity could furthermore be extremely difficult to detect through co-occurrence analysis alone. These results suggest that small differences in strains' adaptations to different immunological regimes, which are shaped by coinfections with other pathogens, can have dramatic effects on strain dynamics and patterns of phenotypic variation. Studies of microbial communities might therefore benefit from the use of varied approaches to infer the presence of indirect interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.