ArticleBMC gastroenterology2012
Risk of esophagus cancer in diabetes mellitus: a population-based case-control study in Taiwan.
Article in BMC gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Association of metformin use with risk and survival outcome of esophageal cancer in patients with diabetes: A systematic review and meta-analysis.PloS one · 2025 · on this mapPooled it
- The Association between the Risk of Esophageal Cancer and Type 2 Diabetes Mellitus: An Updated Meta-Analysis.BioMed research international · 2022Pooled it
- Pooled it
- Dental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in Taiwan.PloS one · 2014Trial
- Tumour catabolism independent of malnutrition and inflammation in upper GI cancer patients revealed by longitudinal metabolomics.Journal of cachexia, sarcopenia and muscle · 2023Article
- Is Type 2 Diabetes Causally Associated With Cancer Risk? Evidence From a Two-Sample Mendelian Randomization Study.Diabetes · 2020Article
- A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells.The Journal of international medical research · 2020Article
- Nomogram for Predicting Risk of Digestive Carcinoma Among Patients with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Case-control study examining the association between hip fracture risk and statins therapy in old people.Medicine · 2019Article
- Fluvastatin use and risk of acute pancreatitis: a population-based case-control study in Taiwan.BioMedicine · 2017Article
- Correlation between proton pump inhibitors and risk of pyogenic liver abscess.European journal of clinical pharmacology · 2017Article
- Etodolac and the risk of acute pancreatitis.BioMedicine · 2017Article
- Immune thrombocytopenic purpura might be an early hematologic manifestation of undiagnosed human immunodeficiency virus infection.Internal and emergency medicine · 2017Article
- Correlation of Proton Pump Inhibitors with Pulmonary Tuberculosis: A Case-Control Study in Taiwan.Frontiers in pharmacology · 2017Article
- Increased Risk of Pulmonary Tuberculosis in Patients with Depression: A Cohort Study in Taiwan.Frontiers in psychiatry · 2017Article
- Case-Control Study Examining the Association between Selective Serotonin Reuptake Inhibitors Use and Hepatocellular Carcinoma.Frontiers in pharmacology · 2017Article
- Article
- Article
- Appendectomy correlates with increased risk of pyogenic liver abscess: A population-based cohort study in Taiwan.Medicine · 2016Article
- Is schizophrenia associated with an increased risk of chronic kidney disease? A nationwide matched-cohort study.BMJ open · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus (DM) has been associated with the cancer risk. This study investigated relationship between DM and esophageal cancer using Taiwan's insurance data.
methodsWe identified 549 patients with esophageal cancer newly diagnosed in 2000-2009 and randomly selected 2196 controls without any cancer, frequency matched by sex, age and diagnosis year of cases. Logistic regression model estimated odds ratios (ORs) and 95% confidence intervals (CI) of esophageal cancer associated with DM, sex, age. co-morbidities and medications.
resultsCases were more prevalent than controls for alcoholism and esophageal disorders and using nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 inhibitors but not DM. Esophageal cancer had no association with DM (OR 0.99, 95% CI 0.71-1.37), but significantly associated with alcoholism (OR 14.1, 95% CI 7.87-25.4), esophageal ulcer (OR 10.1, 95% CI 5.70-17.9), esophageal reflux (OR 3.47, 95% CI 2.14-5.26) and uses of NSAIDs (OR 2.73, 95% CI 1.80-4.13). An elevated risk of esophageal cancer appeared in DM patients taking insulin (OR 2.57, 95% CI 1.08-6.15) or sulfonyurea (OR 3.80, 95% CI 1.16-12.5).
conclusionsPatients with DM are not at higher risk for esophagus cancer. However, esophageal disorders and anti-diabetic drugs are associated with the risk of the disease.
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